Updating the influenza virus library at Hokkaido University : It's potential for the use of pandemic vaccine strain candidates and diagnosis

Nomura, Naoki; Matsuno, Keita; Shingai, Masashi; Ohno, Marumi; Sekiya, Toshiki; Omori, Ryosuke; Sakoda, Yoshihiro; Webster, Robert G.; Kida, Hiroshi

Updating the influenza virus library at Hokkaido University : It's potential for the use of pandemic vaccine strain candidates and diagnosis

Nomura, Naoki; Matsuno, Keita; Shingai, Masashi et al.

Virology, 2021, 557, 55-61

Permalink : https://hdl.handle.net/2115/85184

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/85184
タイトル	Updating the influenza virus library at Hokkaido University : It's potential for the use of pandemic vaccine strain candidates and diagnosis
著者	Nomura, Naoki ; Matsuno, Keita ; Shingai, Masashi ; Ohno, Marumi ; Sekiya, Toshiki ; Omori, Ryosuke ; Sakoda, Yoshihiro ; Webster, Robert G. ; Kida, Hiroshi
著者名 Nomura, Naoki
e-Rad_Researcher 40753306 著者名 Matsuno, Keita
e-Rad_Researcher 80421981 著者名 Shingai, Masashi
e-Rad_Researcher 50794202 著者名 Ohno, Marumi
著者名 Sekiya, Toshiki
e-Rad_Researcher 10746952 著者名 Omori, Ryosuke
e-Rad_Researcher 40333637 著者名 Sakoda, Yoshihiro
著者名 Webster, Robert G.
e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
言語	英語
キーワード	Pandemic influenza vaccine
	Influenza virus library
	Hemagglutinin
発行日	2021-05-01
出版者	Elsevier
収録物名	Virology
巻(号)	557
ページ	55-61
抄録	Genetic reassortment of influenza A viruses through cross-species transmission contributes to the generation of pandemic influenza viruses. To provide information on the ecology of influenza viruses, we have been conducting a global surveillance of zoonotic influenza and establishing an influenza virus library. Of 4580 influenza virus strains in the library, 3891 have been isolated from over 70 different bird species. The remaining 689 strains were isolated from humans, pigs, horses, seal, whale, and the environment. Phylogenetic analyses of the HA genes of the library isolates demonstrate that the library strains are distributed to all major known clusters of the H1, H2 and H3 subtypes of HA genes that are prevalent in humans. Since past pandemic influenza viruses are most likely genetic reassortants of zoonotic and seasonal influenza viruses, a vast collection of influenza A virus strains from various hosts should be useful for vaccine preparation and diagnosis for future pandemics.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Under an Elsevier user license [https://www.elsevier.com/open-access/userlicense/1.0/]
PISSN	0042-6822
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.virol.2021.02.005