Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

Hira, Tohru; Yanagihara, Kurumi; Koga, Toshiki; Takahashi, Keisuke; Nagura, Taizo; Uchino, Hirokatsu; Hara, Hiroshi

Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

Hira, Tohru; Yanagihara, Kurumi; Koga, Toshiki et al.

Bioscience, Biotechnology and Biochemistry, 2017, 81(11), 2186-2194

Permalink : https://hdl.handle.net/2115/85186

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アクセス権	open access
URI	https://hdl.handle.net/2115/85186
タイトル	Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet
著者	Hira, Tohru ; Yanagihara, Kurumi ; Koga, Toshiki ; Takahashi, Keisuke ; Nagura, Taizo ; Uchino, Hirokatsu ; Hara, Hiroshi
e-Rad_Researcher 10396301 著者名 Hira, Tohru
著者名 Yanagihara, Kurumi
著者名 Koga, Toshiki
著者名 Takahashi, Keisuke
著者名 Nagura, Taizo
著者名 Uchino, Hirokatsu
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
言語	英語
キーワード	difructose anhydride III
	raffinose
	fructooligosaccharides
	diet-induced obesity
	GLP-1
発行日	2017
収録物名	Bioscience, Biotechnology and Biochemistry
巻(号)	81(11)
ページ	2186-2194
抄録	We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or FOS, for 8 or 5 weeks. Supplementing DFA III to the HFS diet decreased energy intake compared to the non-supplemented HFS diet. Accordingly, body weight gain and fat accumulation reduced in DFA III-fed rats. Cecal acetate production and plasma glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) were elevated in DFA III-fed rats, while Raf and FOS partially affected these parameters. These results demonstrate that DFA III has suppressive effect on excessive energy intake driven by the palatable obesogenic diet, possibly due to combined effects of increased anorexigenic factors such as cecal acetate production and GLP-1/PYY secretion.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Tohru Hira, Kurumi Yanagihara, Toshiki Koga, Keisuke Takahashi, Taizo Nagura, Hirokatsu Uchino, Hiroshi Hara, Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet, Bioscience, Biotechnology, and Biochemistry, Volume 81, Issue 11, 2 November 2017, Pages 2186–2194 is available online at: https://doi.org/10.1080/09168451.2017.1373591.
PISSN	0916-8451
EISSN	1347-6947
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1080/09168451.2017.1373591