Suppressive Effect on Food Intake of a Potato Extract (Potein®) Involving Cholecystokinin Release in Rats

CHEN, Wenya; HIRA, Tohru; NAKAJIMA, Shingo; TOMOZAWA, Hiroshi; TSUBATA, Masahito; YAMAGUCHI, Kazuya; HARA, Hiroshi

Suppressive Effect on Food Intake of a Potato Extract (Potein®) Involving Cholecystokinin Release in Rats

CHEN, Wenya; HIRA, Tohru; NAKAJIMA, Shingo et al.

Bioscience, Biotechnology and Biochemistry, 2012, 76(6), 1104-1109

Permalink : https://hdl.handle.net/2115/85201

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アクセス権	open access
URI	https://hdl.handle.net/2115/85201
タイトル	Suppressive Effect on Food Intake of a Potato Extract (Potein®) Involving Cholecystokinin Release in Rats
著者	CHEN, Wenya ; HIRA, Tohru ; NAKAJIMA, Shingo ; TOMOZAWA, Hiroshi ; TSUBATA, Masahito ; YAMAGUCHI, Kazuya ; HARA, Hiroshi
著者名 CHEN, Wenya
e-Rad_Researcher 10396301 著者名 HIRA, Tohru
著者名 NAKAJIMA, Shingo
著者名 TOMOZAWA, Hiroshi
著者名 TSUBATA, Masahito
著者名 YAMAGUCHI, Kazuya
e-Rad_Researcher 70198894 著者名 HARA, Hiroshi
言語	英語
キーワード	potato extract
	cholecystokinin
	appetite
	rat
	devazepide
発行日	2012
収録物名	Bioscience, Biotechnology and Biochemistry
巻(号)	76(6)
ページ	1104-1109
抄録	We have recently reported that oral gavage of a potato extract (Potein®) suppressed the food intake in rats. The satiating effect of the potato extract was compared in the present study to other protein sources, and the involvement of endogenous cholecystokinin (CCK) secretion was examined. Food consumption was measured in 18-h fasted rats after oral gavage of the potato extract or other protein sources. The CCK-releasing activity of the potato extract was then examined in anesthetized rats with a portal cannula. Oral gavage of the potato extract reduced the food intake in the rats, the effect being greater than with casein and a soybean β-conglycinin hydrolysate. The suppressive effect on appetite of the potato extract was attenuated by treating with a CCK-receptor antagonist (devazepide). The portal CCK concentration was increased after a duodenal administration of the potato extract to anesthetized rats. These results indicate that the potato extract suppressed the food intake in rats through CCK secretion.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Bioscience biotechnology and biochemistry following peer review. The version of record Wenya CHEN, Tohru HIRA, Shingo NAKAJIMA, Hiroshi TOMOZAWA, Masahito TSUBATA, Kazuya YAMAGUCHI, Hiroshi HARA, Suppressive Effect on Food Intake of a Potato Extract (PoteinR) Involving Cholecystokinin Release in Rats, Bioscience, Biotechnology, and Biochemistry, Volume 76, Issue 6, 23 June 2012, Pages 1104-1109 is available online at: https://doi.org/10.1271/bbb.110936.
PISSN	0916-8451
EISSN	1347-6947
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1271/bbb.110936