High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report

Ishi, Yukitomo; Shimizu, Ai; Takakuwa, Emi; Sugiyama, Minako; Okamoto, Michinari; Motegi, Hiroaki; Hirabayashi, Shinsuke; Cho, Yuko; Iguchi, Akihiro; Manabe, Atsushi; Nobusawa, Sumihito; Tanaka, Shinya; Yamaguchi, Shigeru

High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report

Ishi, Yukitomo; Shimizu, Ai; Takakuwa, Emi et al.

Pathology international, 2021, 71(5), 348-354

Permalink : https://hdl.handle.net/2115/85210

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アクセス権	open access
URI	https://hdl.handle.net/2115/85210
タイトル	High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report
著者	Ishi, Yukitomo ; Shimizu, Ai ; Takakuwa, Emi ; Sugiyama, Minako ; Okamoto, Michinari ; Motegi, Hiroaki ; Hirabayashi, Shinsuke ; Cho, Yuko ; Iguchi, Akihiro ; Manabe, Atsushi ; Nobusawa, Sumihito ; Tanaka, Shinya ; Yamaguchi, Shigeru
e-Rad_Researcher 30812284 著者名 Ishi, Yukitomo
著者名 Shimizu, Ai
著者名 Takakuwa, Emi
著者名 Sugiyama, Minako
著者名 Okamoto, Michinari
著者名 Motegi, Hiroaki
著者名 Hirabayashi, Shinsuke
著者名 Cho, Yuko
著者名 Iguchi, Akihiro
著者名 Manabe, Atsushi
著者名 Nobusawa, Sumihito
著者名 Tanaka, Shinya
著者名 Yamaguchi, Shigeru
言語	英語
キーワード	BCOR
	high-grade neuroepithelial tumor
	pediatric
	PNET
発行日	2021-05
出版者	John Wiley & Sons
収録物名	Pathology international
巻(号)	71(5)
ページ	348-354
抄録	A 5-year-old girl presented with headache and vomiting. Head computed tomography and magnetic resonance imaging showed a right frontal lobe tumor with marked calcification. The patient underwent resection surgery with suspicion of anaplastic ependymoma, and the tumor was gross totally removed. Pathological examination revealed areas of dense tumor cells with a high nucleocytoplasmic ratio and myxoid areas consisting of tumor cells with a round-shaped nucleus and eosinophilic cytoplasm. Perivascular pseudorosette, necrosis, circumscribed growth, and microcalcification were also observed. Immunohistochemistry demonstrated negative staining for glial fibrillary protein and epithelial membrane antigen. Diagnosis of a high-grade neuroepithelial tumor (HGNET) with BCL6 corepressor (BCOR) alteration was made based on pathological findings and internal tandem duplication in the exon 15 of BCOR. Although calcification on radiological and pathological examination is not typical, it would be essential to recognize that calcification could appear in HGNET-BCOR.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Ishi, Y., Shimizu, A., Takakuwa, E., Sugiyama, M., Okamoto, M., Motegi, H., Hirabayashi, S., Cho, Y., Iguchi, A., Manabe, A., Nobusawa, S., Tanaka, S. and Yamaguchi, S. (2021), High-grade neuroepithelial tumor with BCL6 corepressor-alteration presenting pathological and radiological calcification: A case report. Pathology International, 71: 348-354, which has been published in final form at https://doi.org/10.1111/PIN.13083. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
PISSN	1320-5463
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/pin.13083