High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease

Shiratori, Souichi; Ohigashi, Hiroyuki; Ara, Takahide; Yasumoto, Atsushi; Goto, Hideki; Nakagawa, Masao; Sugita, Junichi; Onozawa, Masahiro; Kahata, Kaoru; Endo, Tomoyuki; Hashimoto, Daigo; Teshima, Takanori

High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease

Shiratori, Souichi; Ohigashi, Hiroyuki; Ara, Takahide et al.

Annals of hematology, 2021, 100(5), 1321-1328

Permalink : https://hdl.handle.net/2115/85245

このアイテムのアクセス数:475件（2026-01-19 13:29 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数
Annals of Hematology_s00277-020-04347-1	pdf	444 KB	350
ATG (Lym) Sup Fig1	JPG	81.8 KB	74
ATG (Lym) Sup Fig2	jpg	63.0 KB	113

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/85245
タイトル	High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease
著者	Shiratori, Souichi ; Ohigashi, Hiroyuki ; Ara, Takahide ; Yasumoto, Atsushi ; Goto, Hideki ; Nakagawa, Masao ; Sugita, Junichi ; Onozawa, Masahiro ; Kahata, Kaoru ; Endo, Tomoyuki ; Hashimoto, Daigo ; Teshima, Takanori
e-Rad_Researcher 00645905 著者名 Shiratori, Souichi
e-Rad_Researcher 20845284 著者名 Ohigashi, Hiroyuki
著者名 Ara, Takahide
e-Rad_Researcher 90769887 著者名 Yasumoto, Atsushi
e-Rad_Researcher 70759290 著者名 Goto, Hideki
e-Rad_Researcher 80435859 著者名 Nakagawa, Masao
著者名 Sugita, Junichi
e-Rad_Researcher 70455632 著者名 Onozawa, Masahiro
著者名 Kahata, Kaoru
著者名 Endo, Tomoyuki
e-Rad_Researcher 20419576 著者名 Hashimoto, Daigo
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	Allogeneic hematopoietic stem cell transplantation
	Peripheral blood stem cell transplantation
	Antithymocyte globulin
	Graft-versus-host disease
	Absolute lymphocyte count
発行日	2021-05
出版者	Springer
収録物名	Annals of hematology
巻(号)	100(5)
ページ	1321-1328
抄録	Antithymocyte globulin (ATG) reduces severe acute and chronic graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (PBSCT). However, risk factors for severe acute GVHD in PBSCT using ATG remain to be determined. We conducted a single-center, retrospective study to analyze the association of acute GVHD requiring systemic corticosteroid (SC-aGVHD) with absolute lymphocyte counts (ALC) before the administration of ATG or conditioning in 53 patients with HLA-matched PBSCT using low-dose thymoglobulin (2 mg/kg) after myeloablative conditioning. The cumulative incidence of SC-aGVHD was 17.0% and ALC before ATG were significantly higher in patients with SC-aGVHD compared to that in patients without it (median, 0.15 x 10(9)/L vs 0.06 x 10(9)/L, P = 0.047). The cumulative incidence of SC-aGVHD was significantly higher in patients with high ALC before ATG (>= 0.15 x 10(9)/L) than in those with low ALC (38.5% vs 10.0%, P = 0.016). Non-relapse mortality (NRM) was also significantly higher in the high ALC before ATG group than the low ALC before ATG group (2-year NRM: 23.9% vs 6.0%, P = 0.048), leading to worse survival (2-year overall survival: 69.2% vs 83.5%, P = 0.039). Our study suggested that high ALC before ATG is a risk factor for SC-aGVHD.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Annals of Hematology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00277-020-04347-1
PISSN	0939-5555
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00277-020-04347-1