Feasibility of limited resection for peripheral small-sized non-small cell lung cancer : a retrospective single-center-based study

Aragaki, Masato; Hida, Yasuhiro; Kato, Tatsuya; Fujiwara-Kuroda, Aki; Kaga, Kichizo; Wakasa, Satoru

Feasibility of limited resection for peripheral small-sized non-small cell lung cancer : a retrospective single-center-based study

Aragaki, Masato; Hida, Yasuhiro; Kato, Tatsuya et al.

Journal of cancer research and clinical oncology, 2021, 147, 1519-1527

Permalink : https://hdl.handle.net/2115/85249

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アクセス権	open access
URI	https://hdl.handle.net/2115/85249
タイトル	Feasibility of limited resection for peripheral small-sized non-small cell lung cancer : a retrospective single-center-based study
著者	Aragaki, Masato ; Hida, Yasuhiro ; Kato, Tatsuya ; Fujiwara-Kuroda, Aki ; Kaga, Kichizo ; Wakasa, Satoru
e-Rad_Researcher 30788245 著者名 Aragaki, Masato
e-Rad_Researcher 30399919 著者名 Hida, Yasuhiro
著者名 Kato, Tatsuya
著者名 Fujiwara-Kuroda, Aki
e-Rad_Researcher 80224335 著者名 Kaga, Kichizo
e-Rad_Researcher 10374365 著者名 Wakasa, Satoru
言語	英語
キーワード	Non-small cell lung cancer
	Limited resection
	SUVmax
	Segmentectomy
発行日	2021-05
出版者	Springer
収録物名	Journal of cancer research and clinical oncology
巻(号)	147
ページ	1519-1527
抄録	Purpose This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). Methods Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 who underwent limited resection were enrolled. Criteria for undergoing intentional limited resection (ILR) were (1) tumor ground-glass opacity (GGO) ratio of >= 0.75 and (2) tumor SUVmax <= 1.5. Patients who met criteria (1) and (2) underwent partial resection, and those who only met criteria (2) underwent segmentectomy as ILR. The control group was subjected to limited surgery without meeting the criteria. Results Overall, 45 and 25 patients who met the criteria were included in the ILR and control groups, respectively. In the ILR group, 13 patients underwent partial resection, and 32 underwent segmentectomy; in the control group, 18 patients underwent partial resection and 7 underwent segmentectomy. According to our criteria, no relapsed cases occurred in the ILR group, although six patients showed recurrence of lung cancer in the control group. The 5-year overall survival (OS) rates in the ILR and control groups were 100% and 67.7%, respectively, and the relapse-free survival (RFS) rates were 100% and 61.6%, respectively. The log-rank test showed that this difference was statistically significant (OS: P < 0.0001, RFS: P < 0.0001). Conclusions SUVmax may serve as a predictive marker of recurrence to determine the treatment strategy for patients with NSCLC. Patients with low GGO ratio and low SUVmax may be cured by limited resection.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Journal of Cancer Research and Clinical Oncology. The final authenticated version is available online at: http://dx.doi.org/https://doi.org/10.1007/s00432-020-03441-1
PISSN	0171-5216
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00432-020-03441-1