Effective Synthesis and Antifouling Activity of Dolastatin 16 Derivatives

Casalme, Loida O.; Katayama, Keisuke; Hayakawa, Yoshiki et al.

Marine Drugs, 2022, 20(2), 124

Permalink : https://hdl.handle.net/2115/85339

このアイテムのアクセス数:344件（2026-02-08 16:44 集計）

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https://doi.org/10.3390/md20020124      

論文情報

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アクセス権
metadata only access
URI
https://hdl.handle.net/2115/85339
タイトル
Effective Synthesis and Antifouling Activity of Dolastatin 16 Derivatives
著者
Casalme, Loida O. ; Katayama, Keisuke ; Hayakawa, Yoshiki ; Nakamura, Kensuke ; Yamauchi, Arisa ; Nogata, Yasuyuki ; Yoshimura, Erina ; Matsuda, Fuyuhiko ; Umezawa, Taiki
著者名
Casalme, Loida O.
著者名
Katayama, Keisuke
著者名
Hayakawa, Yoshiki
著者名
Nakamura, Kensuke
著者名
Yamauchi, Arisa
e-Rad_Researcher
10371535
著者名
Nogata, Yasuyuki
著者名
Yoshimura, Erina
e-Rad_Researcher
10219446
著者名
Matsuda, Fuyuhiko
e-Rad_Researcher
20503618
著者名
Umezawa, Taiki
言語
英語
キーワード
natural product
antifouling
dolastatin 16
peptide
Amphibalanus amphitrite
発行日
2022-02
出版者
MDPI
収録物名
Marine Drugs
巻(号)
20(2)
ページ
124
抄録
Some derivatives of dolastatin 16, a depsipeptide natural product first obtained from the sea hare Dolabella auricularia, were synthesized through second-generation synthesis of two unusual amino acids, dolaphenvaline and dolamethylleuine. The second-generation synthesis enabled derivatizations such as functionalization of the aromatic ring in dolaphenvaline. The derivatives of fragments and whole structures were evaluated for antifouling activity against the cypris larvae of Amphibalanus amphitrite. Small fragments inhibited the settlement of the cypris larvae at potent to moderate concentrations (EC50 = 0.60-4.62 mu g/mL), although dolastatin 16 with a substituent on the aromatic ring (24) was much less potent than dolastatin 16.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1660-3397
NCID
AA1203626X
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/md20020124