Usefulness of quantifying serum KL-6 levels in the follow-up of uveitic patients with sarcoidosis

Kitaichi, Nobuyoshi; Ariga, Toshihide; Kase, Satoru; Yoshida, Kauzhiko; Namba, Kenichi; Ohno, Shigeaki

Usefulness of quantifying serum KL-6 levels in the follow-up of uveitic patients with sarcoidosis

Kitaichi, Nobuyoshi; Ariga, Toshihide; Kase, Satoru et al.

Graefes archive for clinical and expermental ophthalmology, 2006, 244(4), 433-437

Permalink : https://hdl.handle.net/2115/8537

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アクセス権	open access
URI	https://hdl.handle.net/2115/8537
タイトル	Usefulness of quantifying serum KL-6 levels in the follow-up of uveitic patients with sarcoidosis
著者	Kitaichi, Nobuyoshi ; Ariga, Toshihide ; Kase, Satoru ; Yoshida, Kauzhiko ; Namba, Kenichi ; Ohno, Shigeaki
e-Rad_Researcher 40431366 著者名 Kitaichi, Nobuyoshi
著者名 Ariga, Toshihide
e-Rad_Researcher 60374394 著者名 Kase, Satoru
著者名 Yoshida, Kauzhiko
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
e-Rad_Researcher 50002382 著者名 Ohno, Shigeaki
言語	英語
キーワード	migration inhibitory factor
	interstitial pneumonia
	ocular involvement
	muci mucin
	increase
	marker
	patterns
	disease
	lung
発行日	2006-04
出版者	Springer
収録物名	Graefes archive for clinical and expermental ophthalmology
巻(号)	244(4)
ページ	433-437
抄録	Background: KL-6 is a human glycoprotein secreted by type II alveolar cells in the lung, and its serum levels increase in pneumonia of various causes. We previously reported that serum KL-6 levels in uveitis patients with sarcoidosis were significantly higher than those of other uveitis patients and healthy controls. Additionally, the combined measurement of serum KL-6 and angiotensin converting enzyme (ACE) was useful for screening uveitic patients to diagnose sarcoidosis. The purpose of the present study was to investigate the clinical usefulness of quantifying serum KL-6 levels for following-up the patients with sarcoidosis. Methods: Sera were obtained from 36 uveitic patients diagnosed with sarcoidosis and the same number of healthy volunteers. To examine the influence of systemic medication, we also collected blood samples from four more sarcoidosis patients, who were systemically treated with corticosteroid or angiotensin converting enzyme (ACE) inhibitor, an anti-hypertensive drug. The serum concentration of KL-6 was measured by a human KL-6 electrochemiluminescence immunoassay (ECLIA). Results: The mean KL-6 concentrations of sarcoidosis patients and healthy controls were 449.3 +/- 66.3 (mean +/- SE) and 192.1 +/- 11.3, respectively. The average levels of serum KL-6 were significantly elevated in sarcoidosis patients compared with healthy control subjects (P < 0.001), and there were significant correlations between serum KL-6 and ACE levels in the patients with sarcoidosis (r=0.70 and P < 0.0001). Moreover, serum KL-6 concentrations were less affected by systemic corticosteroid, and unaffected by ACE inhibitory drugs in contrast to ACE levels. Conclusions: Measurement of serum KL-6 in the uveitic patients may be useful to follow-up the diagnosed sarcoidosis, as well as for diagnosing sarcoidosis, because the serum KL-6 level was well correlated with the ACE level, and less affected by systemic medication than ACE levels.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The origin publication is availabe at www.springerlink.com
PISSN	0721-832X
EISSN	1435-702X
関連情報	PMID 16133026
関連情報	URI http://www.springerlink.com
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00417-005-0081-9