A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice

Lee, Byoung-Hee; Yoshimatsu, Kumiko; Araki, Koichi et al.

Vaccine, 2006, 24(15), 2928-2934

Permalink : https://hdl.handle.net/2115/8543

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/8543
タイトル
A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice
著者
Lee, Byoung-Hee ; Yoshimatsu, Kumiko ; Araki, Koichi ; Okumura, Megumi ; Nakamura, Ichiro ; Arikawa, Jiro
著者名
Lee, Byoung-Hee
著者名
Yoshimatsu, Kumiko
著者名
Araki, Koichi
著者名
Okumura, Megumi
e-Rad_Researcher
20374241
著者名
Nakamura, Ichiro
e-Rad_Researcher
10142704
著者名
Arikawa, Jiro
言語
英語
キーワード
Envelope
Hantavirus
Pseudotype
発行日
2006-04-05
出版者
Elsevier
収録物名
Vaccine
巻(号)
24(15)
ページ
2928-2934
抄録
We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the hantavirus envelope glycoproteins (GPs) G1 and G2 (VSVÎ G*HTN) could be used as a safe and effective alternative to native hantavirus. Mice were immunized with purified particles of VSVÎ G*HTN. After the second immunization, all mice produced anti-GP antibody as detected in ELISA and a neutralization test. After the third immunization, the mice were challenged with Hantaan virus. Neither anti-NP antibody production nor Hantaan virus-specific CD8 T-cell reactions were detected in these mice. The present study demonstrated the potential of using a pseudotype VSV system as a tool for developing a hantavirus vaccine.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0264-410X
関連情報
PMID
16426712
URI
http://www.sciencedirect.com/science/journal/0264410X
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.vaccine.2005.12.040