Ultrasonic irrigation of periodontal pocket with surface pre-reacted glass-ionomer (S-PRG) nanofiller dispersion improves periodontal parameters in beagle dogs

Miyaji, Hirofumi; Mayumi, Kayoko; Kanemoto, Yukimi; Okamoto, Ichie; Hamamoto, Asako; Kato, Akihito; Sugaya, Tsutomu; Akasaka, Tsukasa; Tanaka, Saori

Ultrasonic irrigation of periodontal pocket with surface pre-reacted glass-ionomer (S-PRG) nanofiller dispersion improves periodontal parameters in beagle dogs

Miyaji, Hirofumi; Mayumi, Kayoko; Kanemoto, Yukimi et al.

Journal of Oral Biosciences, 2022, 64(2), 222-228

Permalink : https://hdl.handle.net/2115/85446

このアイテムのアクセス数:396件（2026-01-23 19:50 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/85446
タイトル	Ultrasonic irrigation of periodontal pocket with surface pre-reacted glass-ionomer (S-PRG) nanofiller dispersion improves periodontal parameters in beagle dogs
著者	Miyaji, Hirofumi ; Mayumi, Kayoko ; Kanemoto, Yukimi ; Okamoto, Ichie ; Hamamoto, Asako ; Kato, Akihito ; Sugaya, Tsutomu ; Akasaka, Tsukasa ; Tanaka, Saori
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
著者名 Mayumi, Kayoko
著者名 Kanemoto, Yukimi
著者名 Okamoto, Ichie
著者名 Hamamoto, Asako
e-Rad_Researcher 40507571 著者名 Kato, Akihito
e-Rad_Researcher 10211301 著者名 Sugaya, Tsutomu
e-Rad_Researcher 00360917 著者名 Akasaka, Tsukasa
e-Rad_Researcher 90344522 著者名 Tanaka, Saori
言語	英語
キーワード	16S rRNA next-generation sequencer
	Actinomyces naeslundii
	Antibacterial effect
	Micro-CT
	Surface pre-reacted glass-ionomer (S-PRG) nanofiller
	Ultrasonic scaler system
発行日	2022-03-04
出版者	Elsevier
収録物名	Journal of Oral Biosciences
巻(号)	64(2)
ページ	222-228
抄録	Objectives: Surface pre-reacted glass-ionomer (S-PRG) nanofiller, an antibacterial ion-releasing bioactive glass, has been shown to adhere to tooth surfaces and reported to improve inflammatory parameters in experimental periodontitis. In this study, cementum substrate was irrigated ultrasonically with dispersion to examine in-vitro nanofiller adhesion and antibacterial activity. Moreover, periodontal pockets in a beagle dog were ultrasonically irrigated with dispersion to assess periodontal healing. Methods: The morphology of human cementum irrigated with S-PRG nanofiller dispersion was examined by scanning electron microscopy and energy dispersive X-ray spectrometry. The antibacterial activity of the treated cementum was tested using Actinomyces naeslundii. In addition, experimentally formed periodontal pockets in beagle dog were ultrasonically irrigated with S-PRG nanofiller dispersion. Periodontal parameters (gingival index, bleeding on probing, probing pocket depth, and clinical attachment level) were measured from baseline (0 weeks) through 12 weeks. Moreover, the effects of irrigation with S-PRG nanofiller on changes in periodontal microflora and bone healing were analyzed. Results: After ultrasonic irrigation, S-PRG nanofiller adhered to the cementum and exhibited antibacterial activity. The periodontal parameters were shown to improve following ultrasonic irrigation with S-PRG nanofiller dispersion. Analysis by next-generation sequencing revealed that the ratio of red-complex species decreased in the pockets irrigated with S-PRG nanofiller dispersion. In addition, the S-PRG nanofiller showed the potential to promote bone healing. Conclusions: Ultrasonic irrigation with S-PRG nanofiller dispersion using an ultrasonic scaler system permitted delivery of the S-PRG nanofiller to the root surface, providing improved parameters in experimental periodontitis and modifying the composition of subgingival periodontal microflora.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	13490079
関連情報	PMID 35257846
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.job.2022.02.006