open access

https://hdl.handle.net/2115/85456

Editorial: Non-Coding RNAs in Gastrointestinal and Gynecological Cancers: New Insights Into the Mechanisms of Cancer Therapeutic Resistance

英語

gynecological cancer

2022-05-13

Frontiers in Cell and Developmental Biology

10

893868

Background Chemoresistance is mediated by a variety of molecular mechanisms, including inhibition of drug influx, increased drug efflux, evasion of cell apoptosis, enhanced repair of DNA damage, induction of epithelial-mesenchymal transition (EMT), activation of cancer stem-like features, induction of autophagy, alterations in cancer metabolism, mutations of drug targets, and dynamic interactions between tumor cells and their surrounding microenvironment (Holohan et al., 2013). Tumor cells can become resistant to chemotherapeutic agents through a combination of different mechanisms (Vasan et al., 2019). Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been implicated in chemoresistance (Wang et al., 2019). In this research topic, 21 papers (including thirteen reviews and eight original research articles) that have shed light on the therapeutic resistance mechanisms controlled by non-coding RNAs in human gastrointestinal and gynecological cancers were chosen. The latest findings presented in this Research Topic add to our understanding of the mechanisms by which non-coding RNAs govern cancer cell resistance to chemotherapy, and may also point to meaningful molecular targets that could be utilized to eliminate chemoresistance and increase the survival of cancer patients.

学術雑誌論文

Version of Record

Creative Commons Attribution 4.0 International

2296-634X