Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma

Kase, Satoru; Namba, Kenichi; Iwata, Daiju; Mizuuchi, Kazuomi; Suzuki, Kayo; Ito, Takako; Hase, Keitaro; Kitaichi, Nobuyoshi; Ishida, Susumu

Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma

Kase, Satoru; Namba, Kenichi; Iwata, Daiju et al.

Journal of clinical medicine, 2022, 11(5), 1391

Permalink : https://hdl.handle.net/2115/85490

このアイテムのアクセス数:356件（2026-01-13 06:44 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.3390/jcm11051391

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	metadata only access
URI	https://hdl.handle.net/2115/85490
タイトル	Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma
著者	Kase, Satoru ; Namba, Kenichi ; Iwata, Daiju ; Mizuuchi, Kazuomi ; Suzuki, Kayo ; Ito, Takako ; Hase, Keitaro ; Kitaichi, Nobuyoshi ; Ishida, Susumu
e-Rad_Researcher 60374394 著者名 Kase, Satoru
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
e-Rad_Researcher 70374402 著者名 Iwata, Daiju
e-Rad_Researcher 80598780 著者名 Mizuuchi, Kazuomi
著者名 Suzuki, Kayo
著者名 Ito, Takako
著者名 Hase, Keitaro
著者名 Kitaichi, Nobuyoshi
e-Rad_Researcher 10245558 著者名 Ishida, Susumu
言語	英語
キーワード	vitreoretinal lymphoma
	cell block preparations
	subretinal infiltrates
	optical coherence tomography
発行日	2022-03
出版者	MDPI
収録物名	Journal of clinical medicine
巻(号)	11(5)
ページ	1391
抄録	Purpose: The purpose of this study was to examine the diagnostic accuracy of the cell block (CB) method and clinical features affecting it in patients with vitreoretinal lymphoma (VRL). Methods: This study enrolled 38 eyes in 33 VRL patients, and 7 eyes in 7 patients with idiopathic uveitis who underwent diagnostic vitrectomy. Medical records including the results of CB cytology, interleukin (IL)-10/-6 concentrations, and immunoglobulin heavy chain gene (IgH) rearrangement were retrospectively searched. Results: Patients with VRL comprised 16 women and 17 men, and the age of onset ranged from 44 to 85 years (mean: 70 years). CB preparations detected large malignant cells in 35 eyes (92%), whereas the other 3 VRL eyes were negative. Two of the latter three eyes showed subretinal infiltrates, which existed in 7 of 35 CB-positive eyes. Intravitreal IL-10 and -6 concentrations were 1866 +/- 4088 pg/mL and 98 +/- 139 pg/mL, respectively, and the rate of IL-10/-6 >1 was 86.9%. The presence of IgH monoclonality was 63.2%. In patients with uveitis, CB specimens revealed no atypical but small inflammatory cells. IL-6 concentration was 311.1 +/- 240 pg/mL, whereas IL-10 was undetectable in six eyes, and the IL-negative rate was 85.7%. Six eyes (85.7%) with uveitis showed no IgH monoclonality. Conclusions: Diagnostic accuracy of CB preparations in VRL could achieve an equivalent outcome to IL ratio calculation and IgH monoclonality detection. The appearance of subretinal infiltrates may diminish the CB positivity.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/jcm11051391