Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Suzuki, Rigel; Yamasoba, Daichi; Kimura, Izumi; Wang, Lei; Kishimoto, Mai; Ito, Jumpei; Morioka, Yuhei; Nao, Naganori; Nasser, Hesham; Uriu, Keiya; Kosugi, Yusuke; Tsuda, Masumi; Orba, Yasuko; Sasaki, Michihito; Shimizu, Ryo; Kawabata, Ryoko; Yoshimatsu, Kumiko; Asakura, Hiroyuki; Nagashima, Mami; Sadamasu, Kenji; Yoshimura, Kazuhisa; Sawa, Hirofumi; Ikeda, Terumasa; Irie, Takashi; Matsuno, Keita; Tanaka, Shinya; Fukuhara, Takasuke; Sato, Kei

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

Suzuki, Rigel; Yamasoba, Daichi; Kimura, Izumi et al.

Nature, 2022, 603(7902), 700-705

Permalink : https://hdl.handle.net/2115/85527

このアイテムのアクセス数:444件（2026-02-09 02:51 集計）

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/85527
タイトル	Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant
著者	Suzuki, Rigel ; Yamasoba, Daichi ; Kimura, Izumi ; Wang, Lei ; Kishimoto, Mai ; Ito, Jumpei ; Morioka, Yuhei ; Nao, Naganori ; Nasser, Hesham ; Uriu, Keiya ; Kosugi, Yusuke ; Tsuda, Masumi ; Orba, Yasuko ; Sasaki, Michihito ; Shimizu, Ryo ; Kawabata, Ryoko ; Yoshimatsu, Kumiko ; Asakura, Hiroyuki ; Nagashima, Mami ; Sadamasu, Kenji ; Yoshimura, Kazuhisa ; Sawa, Hirofumi ; Ikeda, Terumasa ; Irie, Takashi ; Matsuno, Keita ; Tanaka, Shinya ; Fukuhara, Takasuke ; Sato, Kei
著者名 Suzuki, Rigel
著者名 Yamasoba, Daichi
著者名 Kimura, Izumi
著者名 Wang, Lei
著者名 Kishimoto, Mai
著者名 Ito, Jumpei
著者名 Morioka, Yuhei
著者名 Nao, Naganori
著者名 Nasser, Hesham
著者名 Uriu, Keiya
著者名 Kosugi, Yusuke
著者名 Tsuda, Masumi
著者名 Orba, Yasuko
著者名 Sasaki, Michihito
著者名 Shimizu, Ryo
著者名 Kawabata, Ryoko
著者名 Yoshimatsu, Kumiko
著者名 Asakura, Hiroyuki
著者名 Nagashima, Mami
著者名 Sadamasu, Kenji
著者名 Yoshimura, Kazuhisa
著者名 Sawa, Hirofumi
著者名 Ikeda, Terumasa
著者名 Irie, Takashi
著者名 Matsuno, Keita
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
e-Rad_Researcher 70598739 著者名 Fukuhara, Takasuke
著者名 Sato, Kei
言語	英語
発行日	2022-03-24
出版者	Nature Portfolio
収録物名	Nature
巻(号)	603(7902)
ページ	700-705
抄録	The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern(1). In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture experiments showed Omicron to be less fusogenic than Delta and than an ancestral strain of SARS-CoV-2.Although the spike (S) protein of Delta is efficiently cleaved into two subunits, which facilitates cell-cell fusion(2,3), the Omicron S protein was less efficiently cleaved compared to the S proteins of Delta and ancestral SARS-CoV-2. Furthermore, in a hamster model, Omicron showed decreased lung infectivity and was less pathogenic compared to Delta and ancestral SARS-CoV-2. Our multiscale investigations reveal the virological characteristics of Omicron, including rapid growth in the human population, lower fusogenicity and attenuated pathogenicity.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0028-0836
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41586-022-04462-1