Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations : The Japan Environment and Children's Study

Miyashita, Chihiro; Saijo, Yasuaki; Ito, Yoshiya; Ikeda-Araki, Atsuko; Itoh, Sachiko; Yamazaki, Keiko; Kobayashi, Sumitaka; Ait Bamai, Yu; Masuda, Hideyuki; Tamura, Naomi; Itoh, Mariko; Yamaguchi, Takeshi; Yamazaki, Shin; Kishi, Reiko

Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations : The Japan Environment and Children's Study

Miyashita, Chihiro; Saijo, Yasuaki; Ito, Yoshiya et al.

International journal of environmental research and public health, 2021, 18(19), 10103

Permalink : https://hdl.handle.net/2115/85571

このアイテムのアクセス数:457件（2026-03-17 04:16 集計）

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https://doi.org/10.3390/ijerph181910103			9

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/85571
タイトル	Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations : The Japan Environment and Children's Study
著者	Miyashita, Chihiro ; Saijo, Yasuaki ; Ito, Yoshiya ; Ikeda-Araki, Atsuko ; Itoh, Sachiko ; Yamazaki, Keiko ; Kobayashi, Sumitaka ; Ait Bamai, Yu ; Masuda, Hideyuki ; Tamura, Naomi ; Itoh, Mariko ; Yamaguchi, Takeshi ; Yamazaki, Shin ; Kishi, Reiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Saijo, Yasuaki
著者名 Ito, Yoshiya
e-Rad_Researcher 00619885 著者名 Ikeda-Araki, Atsuko
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 60732120 著者名 Yamazaki, Keiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
e-Rad_Researcher 90752907 著者名 Ait Bamai, Yu
著者名 Masuda, Hideyuki
e-Rad_Researcher 80836164 著者名 Tamura, Naomi
著者名 Itoh, Mariko
e-Rad_Researcher 80894972 著者名 Yamaguchi, Takeshi
著者名 Yamazaki, Shin
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	metallic elements
	abdominal congenital malformations
	prenatal exposure
発行日	2021-10
出版者	MDPI
収録物名	International journal of environmental research and public health
巻(号)	18(19)
ページ	10103
抄録	Abdominal congenital malformations are responsible for early mortality, inadequate nutrient intake, and infant biological dysfunction. Exposure to metallic elements in utero is reported to be toxic and negatively impacts ontogeny. However, no prior study has sufficiently evaluated the effects of exposure to metallic elements in utero on abdominal congenital malformations. The aim of the present study was to evaluate associations between metallic elements detected in maternal blood during pregnancy and congenital abdominal malformations. Data from participants in the Japan Environment and Children's Study was used in the present study, and contained information on singleton and live birth infants without congenital abnormalities (control: n = 89,134) and abdominal malformations (case: n = 139). Heavy metals such as mercury (Hg), lead (Pb), cadmium (Cd), and trace elements of manganese (Mn) and selenium (Se) were detected in maternal serum samples during mid- and late-gestation. Infant congenital abnormalities were identified from delivery records at birth or one month after birth by medical doctors. In a multivariate analysis adjusted to account for potential confounders, quartiles of heavy metals and trace elements present in maternal blood were not statistically correlated to the prevalence of abdominal congenital malformations at birth. This study is the first to reveal the absence of significant associations between exposure levels to maternal heavy metals and trace elements in utero and the prevalence of abdominal congenital malformations in a large cohort of the Japanese population. Further studies are necessary to investigate the impact of exposure to heavy metals and trace elements via maternal blood in offspring after birth.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijerph181910103