The Ameliorative Effect of Dexamethasone on the Development of Autoimmune Lung Injury and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model

Elewa, Yaser Hosny Ali; Masum, Md Abdul; Mohamed, Sherif Kh A.; Islam, Md Rashedul; Nakamura, Teppei; Ichii, Osamu; Kon, Yasuhiro

The Ameliorative Effect of Dexamethasone on the Development of Autoimmune Lung Injury and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model

Elewa, Yaser Hosny Ali; Masum, Md Abdul; Mohamed, Sherif Kh A. et al.

International Journal of Molecular Sciences, 2022, 23(8), 4449

Permalink : https://hdl.handle.net/2115/85601

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https://doi.org/10.3390/ijms23084449

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/85601
タイトル	The Ameliorative Effect of Dexamethasone on the Development of Autoimmune Lung Injury and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model
著者	Elewa, Yaser Hosny Ali ; Masum, Md Abdul ; Mohamed, Sherif Kh A. ; Islam, Md Rashedul ; Nakamura, Teppei ; Ichii, Osamu ; Kon, Yasuhiro
ORCID 0000-0002-7347-4587 著者名 Elewa, Yaser Hosny Ali
著者名 Masum, Md Abdul
著者名 Mohamed, Sherif Kh A.
著者名 Islam, Md Rashedul
e-Rad_Researcher 80786773 著者名 Nakamura, Teppei
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
言語	英語
キーワード	autoimmune disease mouse model
	dexamethasone
	high endothelial venules
	lung injury
	lymphatic vessels
	mediastinal fat-associated lymphoid cluster
	proliferating cells
発行日	2022-04-18
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	23(8)
ページ	4449
抄録	In our previous study, we revealed the ameliorative therapeutic effect of dexamethasone (Dex) for Lupus nephritis lesions in the MRL/MpJ-Fas (lpr/lpr) (Lpr) mouse model. The female Lpr mice developed a greater number of mediastinal fat-associated lymphoid clusters (MFALCs) and inflammatory lung lesions compared to the male mice. However, the effect of Dex, an immunosuppressive drug, on both lung lesions and the development of MFALCs in Lpr mice has not been identified yet. Therefore, in this study, we compared the development of lung lesions and MFALCs in female Lpr mice that received either saline (saline group "SG") or dexamethasone (dexamethasone group "DG") in drinking water as a daily dose along with weekly intraperitoneal injections for 10 weeks. Compared to the SG group, the DG group showed a significant reduction in the levels of serum anti-dsDNA antibodies, the size of MFALCs, the degree of lung injury, the area of high endothelial venules (HEVs), and the number of proliferating and immune cells in both MFALCs and the lungs. A significant positive correlation was observed between the size of MFALCs and the cellular aggregation in the lungs of Lpr mice. Therefore, this study confirmed the ameliorative effect of Dex on the development of lung injury and MFALCs via their regressive effect on both immune cells' proliferative activity and the development of HEVs. Furthermore, the reprogramming of MFALCs by targeting immune cells and HEVs may provide a therapeutic strategy for autoimmune-disease-associated lung injury.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1422-0067
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijms23084449