Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript

Miyashita, Naoki; Onozawa, Masahiro; Suto, Keito; Fujisawa, Shinichi; Okazaki, Nanase; Hidaka, Daisuke; Ohigashi, Hiroyuki; Yasumoto, Atsushi; Sugita, Junichi; Hashimoto, Daigo; Matsuno, Yoshihiro; Teshima, Takanori

Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript

Miyashita, Naoki; Onozawa, Masahiro; Suto, Keito et al.

Internal medicine, 2022, 61(7), 1049-1054

Permalink : https://hdl.handle.net/2115/85622

このアイテムのアクセス数:369件（2026-01-14 07:14 集計）

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https://doi.org/10.2169/internalmedicine.8319-21

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/85622
タイトル	Aleukemic Extramedullary Blast Crisis as an Initial Presentation of Chronic Myeloid Leukemia with E1A3 BCR-ABL1 Fusion Transcript
著者	Miyashita, Naoki ; Onozawa, Masahiro ; Suto, Keito ; Fujisawa, Shinichi ; Okazaki, Nanase ; Hidaka, Daisuke ; Ohigashi, Hiroyuki ; Yasumoto, Atsushi ; Sugita, Junichi ; Hashimoto, Daigo ; Matsuno, Yoshihiro ; Teshima, Takanori
著者名 Miyashita, Naoki
e-Rad_Researcher 70455632 著者名 Onozawa, Masahiro
著者名 Suto, Keito
著者名 Fujisawa, Shinichi
著者名 Okazaki, Nanase
著者名 Hidaka, Daisuke
e-Rad_Researcher 20845284 著者名 Ohigashi, Hiroyuki
e-Rad_Researcher 90769887 著者名 Yasumoto, Atsushi
著者名 Sugita, Junichi
e-Rad_Researcher 20419576 著者名 Hashimoto, Daigo
e-Rad_Researcher 00199829 著者名 Matsuno, Yoshihiro
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	e1a3
	extramedullary blast crisis
	Philadelphia (Ph) chromosome
	BCR-ABL1
発行日	2022-04-01
出版者	日本内科学会(The Japanese Society of Internal Medicine)
収録物名	Internal medicine
巻(号)	61(7)
ページ	1049-1054
抄録	Right neck swelling and pain occurred in a 49-year-old man. A Blood count showed a slight increase in platelet count without leukemoid reaction. After a biopsy of the cervical mass and bone marrow aspiration, a diagnosis of extramedullary blast crisis (EBC) of chronic myeloid leukemia (CML) was made. Fluorescence in situ hybridization (FISH) analysis showed a BCR-ABL1 fusion signal, but results of real-time polymerase chain reaction (RT-PCR) for major and minor BCR-ABL1 transcripts were negative. We identified a rare e1a 3 BCR-ABL1 fusion transcript. Administration of dasatinib resulted in disappearance of the extramedullary tumor. This is the first reported case of CML-EBC with e1a3 transcript. An aleukemic extramedullary tumor can be the initial presentation of CML.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-2918
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2169/internalmedicine.8319-21