Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level

Ohira, Masafumi; Yokoo, Hideki; Ogawa, Koji; Fukai, Moto; Kamiyama, Toshiya; Sakamoto, Naoya; Taketomi, Akinobu

Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level

Ohira, Masafumi; Yokoo, Hideki; Ogawa, Koji et al.

Carcinogenesis, 2021, 42(6), 794-803

Permalink : https://hdl.handle.net/2115/85683

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/85683
タイトル	Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level
著者	Ohira, Masafumi ; Yokoo, Hideki ; Ogawa, Koji ; Fukai, Moto ; Kamiyama, Toshiya ; Sakamoto, Naoya ; Taketomi, Akinobu
著者名 Ohira, Masafumi
著者名 Yokoo, Hideki
e-Rad_Researcher 20735188 著者名 Ogawa, Koji
e-Rad_Researcher 60374344 著者名 Fukai, Moto
e-Rad_Researcher 80322816 著者名 Kamiyama, Toshiya
e-Rad_Researcher 10334418 著者名 Sakamoto, Naoya
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
言語	英語
発行日	2021-06
出版者	Oxford University Press
収録物名	Carcinogenesis
巻(号)	42(6)
ページ	794-803
抄録	Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and is related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker in HCC and its clinical significance in HCC progression. We compared the sFABP5 concentration in patients with HCC (HCC group) with that of patients with hepatitis without HCC (hepatitis group). Moreover, we measured the FABP5 expression levels in resected HCC tissues (tFABP5) and analyzed their relationship with sFABP5. We also performed cell-based assays using FABP5 knockout and overexpressing HCC cell lines to analyze the effect of extrinsic FABP5 (exFABP5) on HCC cells. We showed that sFABP5 was not a useful tumor marker for HCC, as HCC and sFABP5 were not correlated. However, sFABP5 and tFABP5 significantly correlated with survival after surgery for HCC, while sFABP5 and tFABP5 were independent of each other. In cell-based assays, exFABP5 was taken up by HCC cell lines and positively affected cell survival under glucose-depleted conditions by complementing the endogenous FABP5 function. In conclusion, sFABP5 had a significant impact on HCC progression irrespective of tFABP5 by augmenting cell viability under glucose-depleted conditions. As tFABP5 and 5FABP5 are important factors that are independent of each other in HCC progression, both of them should be considered independently in improving the prognosis of patients with HCC.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Carcinogenesis following peer review. The version of record Masafumi Ohira, Hideki Yokoo, Koji Ogawa, Moto Fukai, Toshiya Kamiyama, Naoya Sakamoto, Akinobu Taketomi, Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level, Carcinogenesis, Volume 42, Issue 6, June 2021, Pages 794–803 is available online at: https://doi.org/10.1093/carcin/bgab025.
PISSN	0143-3334
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/carcin/bgab025