open access

https://hdl.handle.net/2115/86157

Disruption of model-based decision making by silencing of serotonin neurons in the dorsal raphe nucleus

英語

habitual

2021-06-07

Cell Press

Current biology

31(11)

2446-2454.e5

Adaptingto changing environmentalconditions requires a prospective inferenceof future actionsandtheir consequences, a strategy alsoknownasmodel-baseddecisionmaking.(1-3) In stable environments, extensive experience of actions and their consequences leads to a shift fromamodel-based to amodel-free strategy, whereby behavioral selection is primarily governed by retrospective experiences of positive and negative outcomes. Human and animal studies, where subjects are required to speculate about implicit information and adjust behavioral responses overmultiple sessions, point to a role for the central serotonergic systeminmodel-based decision making.(4-8) However, to directly test a causal relationship between serotonergic activity and model-based decision making, phase-specific manipulation of serotonergic activity is needed in a one-shot test, where learning by trial and error is neutralized. Moreover, the serotonergic origin responsible for this effect is yet to be determined. Herein, we demonstrate that optogenetic silencing of serotonin neurons in the dorsal raphe nucleus, but not in the median raphe nucleus, disrupts model-based decision making in lithium-induced outcome devaluation tasks.(9-11) Our data indicate that the serotonergic behavioral effects are not due to increased locomotor activity, anxiolytic effects, or working memory deficits. Our findings provide insights into the neural mechanisms underlying neural weighting between model-free and model-based strategies.

学術雑誌論文

Accepted Manuscript

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

0960-9822