Preexisting autoimmune disease is a risk factor for immune-related adverse events : a meta-analysis

Yamaguchi, Atsushi; Saito, Yoshitaka; Okamoto, Keisuke; Narumi, Katsuya; Furugen, Ayako; Takekuma, Yoh; Sugawara, Mitsuru; Kobayashi, Masaki

Preexisting autoimmune disease is a risk factor for immune-related adverse events : a meta-analysis

Yamaguchi, Atsushi; Saito, Yoshitaka; Okamoto, Keisuke et al.

Supportive care in cancer, 2021, 29, 7747-7753

Permalink : https://hdl.handle.net/2115/86173

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アクセス権	open access
URI	https://hdl.handle.net/2115/86173
タイトル	Preexisting autoimmune disease is a risk factor for immune-related adverse events : a meta-analysis
著者	Yamaguchi, Atsushi ; Saito, Yoshitaka ; Okamoto, Keisuke ; Narumi, Katsuya ; Furugen, Ayako ; Takekuma, Yoh ; Sugawara, Mitsuru ; Kobayashi, Masaki
e-Rad_Researcher 50344495 著者名 Yamaguchi, Atsushi
e-Rad_Researcher 00835001 著者名 Saito, Yoshitaka
著者名 Okamoto, Keisuke
e-Rad_Researcher 90746752 著者名 Narumi, Katsuya
e-Rad_Researcher 90767261 著者名 Furugen, Ayako
e-Rad_Researcher 00396293 著者名 Takekuma, Yoh
e-Rad_Researcher 60332467 著者名 Sugawara, Mitsuru
e-Rad_Researcher 70431319 著者名 Kobayashi, Masaki
言語	英語
キーワード	Immune checkpoint inhibitors (ICIs)
	Immune-related adverse events (irAEs)
	Preexisting autoimmune disease (PAD)
	Meta-analysis
発行日	2021-06-23
出版者	Springer
収録物名	Supportive care in cancer
巻(号)	29
ページ	7747-7753
抄録	Purpose Patients with preexisting autoimmune disease (PAD) are often excluded from clinical trials assessing immune checkpoint inhibitors (ICIs). Therefore, the safety of ICI therapy in patients with PAD remains unclear. Herein, we evaluated the incidence of immune-related adverse events (irAEs) in patients with PAD when compared with non-PAD patients. Methods We searched MEDLINE/PubMed, Web of Science, and Google Scholar for eligible studies from inception to January 2021. Observational studies reporting the incidence of irAEs in patients with and without PAD were included. We then performed a meta-analysis of eligible studies using forest plots. The primary endpoint of this study was the incidence rate of irAEs between patients with and without PAD. Results We identified three prospective and three retrospective studies involving 206 patients with PAD and 3078 patients without PAD. In the meta-analysis, 128 patients with PAD (62.1%) experienced irAEs, which occurred in 51.9% of non-PAD patients, resulting in an odds ratio (OR) of 2.14 (95% confidence interval [CI] 1.58–2.89). In the subgroup analysis, the incidence of irAEs was significantly higher in patients with PAD (OR = 2.19, 95% CI [1.55–3.08]). Furthermore, no significant heterogeneity or publication bias was detected, indicating that our meta-analysis could be generalized to clinical settings. Conclusion This meta-analysis demonstrated that PAD was a risk factor for irAE incidence. These results suggest that monitoring the occurrence of irAEs in patients with PAD is required to manage irAEs appropriately.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Supportive care in cancer. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00520-021-06359-7
PISSN	0941-4355
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00520-021-06359-7