Estradiol-induced immune suppression via prostaglandin E-2 during parturition in bovine leukemia virus-infected cattle

Sajiki, Yamato; Konnai, Satoru; Okagawa, Tomohiro; Maekawa, Naoya; Goto, Shinya; Kohara, Junko; Nitanai, Atsushi; Takahashi, Hirofumi; Kubota, Kentaro; Takeda, Hiroshi; Murata, Shiro; Ohashi, Kazuhiko

Estradiol-induced immune suppression via prostaglandin E-2 during parturition in bovine leukemia virus-infected cattle

Sajiki, Yamato; Konnai, Satoru; Okagawa, Tomohiro et al.

PLoS ONE, 2022, 17(3), e0263660

Permalink : https://hdl.handle.net/2115/86222

このアイテムのアクセス数:411件（2026-08-15 08:08 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/86222
タイトル	Estradiol-induced immune suppression via prostaglandin E-2 during parturition in bovine leukemia virus-infected cattle
著者	Sajiki, Yamato ; Konnai, Satoru ; Okagawa, Tomohiro ; Maekawa, Naoya ; Goto, Shinya ; Kohara, Junko ; Nitanai, Atsushi ; Takahashi, Hirofumi ; Kubota, Kentaro ; Takeda, Hiroshi ; Murata, Shiro ; Ohashi, Kazuhiko
著者名 Sajiki, Yamato
e-Rad_Researcher 40396304 著者名 Konnai, Satoru
e-Rad_Researcher 80829036 著者名 Okagawa, Tomohiro
e-Rad_Researcher 70829035 著者名 Maekawa, Naoya
著者名 Goto, Shinya
著者名 Kohara, Junko
著者名 Nitanai, Atsushi
著者名 Takahashi, Hirofumi
著者名 Kubota, Kentaro
著者名 Takeda, Hiroshi
e-Rad_Researcher 10579163 著者名 Murata, Shiro
e-Rad_Researcher 90250498 著者名 Ohashi, Kazuhiko
言語	英語
発行日	2022-03-09
出版者	PLOS
収録物名	PLoS ONE
巻(号)	17(3)
ページ	e0263660
抄録	Immune suppression during pregnancy and parturition is considered a risk factor that is related to the progression of bovine chronic diseases, such as bovine leukosis, which is caused by bovine leukemia virus (BLV). Our previous studies have demonstrated that prostaglandin E-2 (PGE(2)) suppresses BLV-specific Th1 responses and contributes to the disease progression during BLV infection. Although PGE(2) reportedly plays important roles in the induction of parturition, PGE(2) involvement in immune suppression during parturition is unknown. To investigate its involvement, we analyzed PGE(2) kinetics and Th1 responses in BLV-infected pregnant cattle. PGE(2) concentrations in sera were increased, whereas IFN-gamma responses were decreased before delivery. PGE(2) is known to suppress Th1 immune responses in cattle. Thus, these data suggest that PGE(2) upregulation inhibits Th1 responses during parturition. We also found that estradiol was important for PGE(2) induction in pregnant cattle. In vitro analyses indicated that estradiol suppressed IFN-gamma production, at least in part, via PGE(2)/EP4 signaling. In vivo analyses showed that estradiol administration significantly influenced the induction of PGE(2) production and impaired Th1 responses. Our data suggest that estradiol-induced PGE(2) is involved in the suppression of Th1 responses during pregnancy and parturition in cattle, which could contribute to the progression of BLV infection.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0263660