Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation

Nishida, Mutsumi; Sugita, Junichi; Takahashi, Shuichiro; Iwai, Takahito; Sato, Megumi; Kudo, Yusuke; Omotehara, Satomi; Horie, Tatsunori; Sakano, Ryosuke; Shibuya, Hitoshi; Yokota, Isao; Iguchi, Akihiro; Teshima, Takanori

Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation

Nishida, Mutsumi; Sugita, Junichi; Takahashi, Shuichiro et al.

International journal of hematology, 2021, 114(1), 94-101

Permalink : https://hdl.handle.net/2115/86227

このアイテムのアクセス数:704件（2026-01-14 16:03 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/86227
タイトル	Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
著者	Nishida, Mutsumi ; Sugita, Junichi ; Takahashi, Shuichiro ; Iwai, Takahito ; Sato, Megumi ; Kudo, Yusuke ; Omotehara, Satomi ; Horie, Tatsunori ; Sakano, Ryosuke ; Shibuya, Hitoshi ; Yokota, Isao ; Iguchi, Akihiro ; Teshima, Takanori
e-Rad_Researcher 90404722 著者名 Nishida, Mutsumi
著者名 Sugita, Junichi
著者名 Takahashi, Shuichiro
著者名 Iwai, Takahito
著者名 Sato, Megumi
著者名 Kudo, Yusuke
著者名 Omotehara, Satomi
著者名 Horie, Tatsunori
著者名 Sakano, Ryosuke
著者名 Shibuya, Hitoshi
e-Rad_Researcher 20761414 著者名 Yokota, Isao
著者名 Iguchi, Akihiro
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	Sinusoidal obstruction syndrome
	Veno-occlusive disease
	Ultrasonography
	Color Doppler
	Hematopoietic stem cell transplantation
発行日	2021-07
出版者	Springer
収録物名	International journal of hematology
巻(号)	114(1)
ページ	94-101
抄録	Hepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease is a life-threatening complication after hematopoietic stem cell transplantation (HSCT). We previously reported the efficacy of the Hokkaido Ultrasonography (US)-based scoring system (HokUS-10) for US findings. To establish easier-to-use criteria, we retrospectively evaluated US findings from 441 patients, including 30 patients with SOS using the HokUS-10 scoring system. Using logistic regression analysis, we established the novel diagnostic criteria HokUS-6. In the presence of ascites, US diagnosis was made in the presence of two of the following 6 parameters: moderate amount of ascites, the appearance of a paraumbilical vein blood flow signal, gallbladder wall thickening, portal vein dilatation, portal vein velocity decrease, and hepatic artery resistive index increase. The AUC, sensitivity, and specificity of HokUS-6 were 0.974 (95% confidence interval 0.962-0.990), 95.2%, and 96.9%, respectively. The scores were significantly higher in patients with severe SOS than in those with non-severe SOS (p = 0.013). Furthermore, the scores before HSCT were significantly higher in patients who developed SOS than in controls (p = 0.001). The HokUS-6 is an easy and useful way to diagnose and identify the risk of SOS.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in International journal of hematology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12185-021-03137-3
PISSN	0925-5710
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12185-021-03137-3