Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population

Nimako, Collins; Ichise, Takahiro; Hasegawa, Hiroshi; Akoto, Osei; Boadi, Nathaniel O.; Taira, Kumiko; Fujioka, Kazutoshi; Isoda, Norikazu; Nakayama, Shouta M. M.; Ishizuka, Mayumi; Ikenaka, Yoshinori

Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population

Nimako, Collins; Ichise, Takahiro; Hasegawa, Hiroshi et al.

Environment international, 2022, 162, 107169

Permalink : https://hdl.handle.net/2115/86237

このアイテムのアクセス数:406件（2026-01-15 05:12 集計）

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https://doi.org/10.1016/j.envint.2022.107169

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/86237
タイトル	Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population
著者	Nimako, Collins ; Ichise, Takahiro ; Hasegawa, Hiroshi ; Akoto, Osei ; Boadi, Nathaniel O. ; Taira, Kumiko ; Fujioka, Kazutoshi ; Isoda, Norikazu ; Nakayama, Shouta M. M. ; Ishizuka, Mayumi ; Ikenaka, Yoshinori
著者名 Nimako, Collins
著者名 Ichise, Takahiro
著者名 Hasegawa, Hiroshi
著者名 Akoto, Osei
著者名 Boadi, Nathaniel O.
著者名 Taira, Kumiko
著者名 Fujioka, Kazutoshi
e-Rad_Researcher 80615732 著者名 Isoda, Norikazu
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
言語	英語
キーワード	Neonicotinoid insecticide
	Organic diet
	Conventional diet
	Health risk assessment
	Relative potency factor (RPF)
	Estimated daily intakes (EDI)
発行日	2022-03-26
出版者	Elsevier
収録物名	Environment international
巻(号)	162
ページ	107169
抄録	Neonicotinoid insecticides (NNIs) are a popular class of insecticides used in various pest management regimens worldwide. Biomonitoring studies continuously report high exposure rates of NNIs in various human populations across the globe. Yet, there is no validated countermeasure for combating the recent exponential rise in NNI exposure rates observed in human populations. The current study assessed the impacts of organic dietary interventions on NNI exposure rates in a Japanese population. A total of 103 volunteers were recruited into the study. Subjects were either served with Organic diets for 5 and 30 days or conventional diets. A total of 919 repeated urine samples were collected from the participants and then subjected to LC-MS/MS analysis to determine urinary concentrations of 7 NNIs parent compounds and an NNI metabolite. Eight NNIs were detected; with a decreasing detection frequency (%Dfs) pattern; desmethyl-acetamiprid (dm-ACE) (64.96%) > dinotefuran (52.12%), imidacloprid (39.61%) > clothianidin (33.95%) > thiamethoxam (28.51%) > acetamiprid (12.62%) > nitenpyram (5.33%) > thiacloprid (2.83%). Dinotefuran, dm-ACE, and clothianidin recorded the highest concentrations in the subjects. The %Df of NNIs in the 5-days or 30-days organic diet group were lower than those of the conventional diet consumers. The organic diet group showed lower rates of multiple NNI exposures than those of the conventional diet consumers. The mean and median cumulative levels of NNIs (median IMIeq) were significantly lower in the organic diet group than the conventional diet group (p < 0.0001). The estimated daily intakes (EDIs) of NNIs were higher in adults than children, but less than 1% of NNI cRfDs, except for clothianidin, which exhibited a %cRfD of 1.32 in children. Compared to the conventional diet group, the 5-and 30-day organic dietary intervention showed drastic reductions in NNI EDIs. Findings from the present study give credence to organic dietary interventions as potential ameliorative strategies for NNI exposure rates in human populations.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0160-4120
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.envint.2022.107169