Argicyclamides A-C Unveil Enzymatic Basis for Guanidine Bis-prenylation

Phan, Chin-Soon; Matsuda, Kenichi; Balloo, Nandani; Fujita, Kei; Wakimoto, Toshiyuki; Okino, Tatsufumi

Argicyclamides A-C Unveil Enzymatic Basis for Guanidine Bis-prenylation

Phan, Chin-Soon; Matsuda, Kenichi; Balloo, Nandani et al.

Journal of the American Chemical Society, 2021, 143(27), 10083-10087

Permalink : https://hdl.handle.net/2115/86275

このアイテムのアクセス数:450件（2026-10-11 06:30 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/86275
タイトル	Argicyclamides A-C Unveil Enzymatic Basis for Guanidine Bis-prenylation
著者	Phan, Chin-Soon ; Matsuda, Kenichi ; Balloo, Nandani ; Fujita, Kei ; Wakimoto, Toshiyuki ; Okino, Tatsufumi
著者名 Phan, Chin-Soon
e-Rad_Researcher 50812301 著者名 Matsuda, Kenichi
著者名 Balloo, Nandani
著者名 Fujita, Kei
e-Rad_Researcher 70363900 著者名 Wakimoto, Toshiyuki
e-Rad_Researcher 30280910 著者名 Okino, Tatsufumi
言語	英語
発行日	2021-07-14
出版者	American Chemical Society
収録物名	Journal of the American Chemical Society
巻(号)	143(27)
ページ	10083-10087
抄録	Guanidine prenylation is an outstanding modification in alkaloid and peptide biosynthesis, but its enzymatic basis has remained elusive. We report the isolation of argicyclamides, a new class of cyanobactins with unique mono- and bis-prenylations on guanidine moieties, from Microcystis aeruginosa NIES-88. The genetic basis of argicyclamide biosynthesis was established by the heterologous expression and in vitro characterization of biosynthetic enzymes including AgcF, a new guanidine prenyltransferase. This study provides important insight into the biosynthesis of prenylated guanidines and offers a new toolkit for peptide modification.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-VPFBI4B9YGSJDXAZUSAW
PISSN	0002-7863
NCID	AA00692602
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1021/jacs.1c05732