Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy

Shimoda, Yoshihiko; Shimizu, Yuichi; Takahashi, Hiroaki et al.

BMC gastroenterology, 2022, 22(1), 259

Permalink : https://hdl.handle.net/2115/86296

このアイテムのアクセス数:415件（2026-10-09 17:54 集計）

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https://doi.org/10.1186/s12876-022-02335-5     19

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/86296
タイトル
Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy
著者
Shimoda, Yoshihiko ; Shimizu, Yuichi ; Takahashi, Hiroaki ; Okahara, Satoshi ; Miyake, Takakazu ; Ichihara, Shin ; Tanaka, Ikko ; Inoue, Masaki ; Kinowaki, Sayoko ; Ono, Masayoshi ; Yamamoto, Keiko ; Ono, Shoko ; Sakamoto, Naoya
著者名
Shimoda, Yoshihiko
著者名
Shimizu, Yuichi
著者名
Takahashi, Hiroaki
著者名
Okahara, Satoshi
著者名
Miyake, Takakazu
著者名
Ichihara, Shin
著者名
Tanaka, Ikko
著者名
Inoue, Masaki
著者名
Kinowaki, Sayoko
著者名
Ono, Masayoshi
著者名
Yamamoto, Keiko
著者名
Ono, Shoko
e-Rad_Researcher
10334418
著者名
Sakamoto, Naoya
言語
英語
キーワード
Diagnostic accuracy
Endocytoscopy
Esophageal cancer
Intraepithelial neoplasia
Optical biopsy
発行日
2022
出版者
BioMed Central
収録物名
BMC gastroenterology
巻(号)
22(1)
ページ
259
抄録
Background Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet undergone histological diagnosis was evaluated. We conducted a surveillance study for patients in a high-risk group of esophageal squamous cell carcinoma (ESCC) and evaluated the in vivo histological diagnostic accuracy of ECS. Methods This study was a multicenter prospective study. We enrolled 197 patients in the study between September 1, 2019 and November 30, 2020. The patients first underwent white light imaging and narrow band imaging, and ultra-high magnifying observation was performed if there was a lesion suspected to be an esophageal tumor. Endoscopic submucosal dissection (ESD) was later performed for lesions that were diagnosed to be ESCC by ECS without biopsy. We evaluated the diagnostic accuracy of ECS for esophageal tumorous lesions. Results ESD was performed for 37 patients (41 lesions) who were diagnosed as having ESCC by ECS, and all of them were histopathologically diagnosed as having ESCC. The sensitivity [95% confidence interval (CI)] was 97.6% (87.7-99.7%), specificity (95% CI) was 100% (92.7-100%), diagnostic accuracy (95% CI) was 98.9% (94.0-99.8%), positive predictive value (PPV) (95% CI) was 100% (91.4-100%) and negative predictive value (NPV) (95% CI) was 98.0% (89.5-99.7%). Conclusions ECS has a high diagnostic accuracy and there were no false positives in cases diagnosed and resected as ESCC. Optical biopsy by using ECS for esophageal lesions that are suspected to be tumorous is considered to be sufficient in clinical practice.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s12876-022-02335-5