The utility of diffusion-weighted T2 mapping for the prediction of histological tumor grade in patients with head and neck squamous cell carcinoma

Fujima, Noriyuki; Shimizu, Yukie; Yoneyama, Masami; Nakagawa, Junichi; Kameda, Hiroyuki; Harada, Taisuke; Hamada, Seijiro; Suzuki, Takayoshi; Tsushima, Nayuta; Kano, Satoshi; Homma, Akihiro; Kudo, Kohsuke

The utility of diffusion-weighted T2 mapping for the prediction of histological tumor grade in patients with head and neck squamous cell carcinoma

Fujima, Noriyuki; Shimizu, Yukie; Yoneyama, Masami et al.

Quantitative imaging in medicine and surgery, 2022, 12(8), 4024-4032

Permalink : https://hdl.handle.net/2115/86304

このアイテムのアクセス数:571件（2026-10-14 01:15 集計）

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https://doi.org/10.21037/qims-22-136			22

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アクセス権	open access
URI	https://hdl.handle.net/2115/86304
タイトル	The utility of diffusion-weighted T2 mapping for the prediction of histological tumor grade in patients with head and neck squamous cell carcinoma
著者	Fujima, Noriyuki ; Shimizu, Yukie ; Yoneyama, Masami ; Nakagawa, Junichi ; Kameda, Hiroyuki ; Harada, Taisuke ; Hamada, Seijiro ; Suzuki, Takayoshi ; Tsushima, Nayuta ; Kano, Satoshi ; Homma, Akihiro ; Kudo, Kohsuke
e-Rad_Researcher 80431360 著者名 Fujima, Noriyuki
著者名 Shimizu, Yukie
著者名 Yoneyama, Masami
著者名 Nakagawa, Junichi
著者名 Kameda, Hiroyuki
著者名 Harada, Taisuke
著者名 Hamada, Seijiro
著者名 Suzuki, Takayoshi
著者名 Tsushima, Nayuta
著者名 Kano, Satoshi
著者名 Homma, Akihiro
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
言語	英語
キーワード	Diffusion
	T2 mapping
	head and neck squamous cell carcinoma (SCC)
	histological grade
発行日	2022-07-15
出版者	AME Publishing Company
収録物名	Quantitative imaging in medicine and surgery
巻(号)	12(8)
ページ	4024-4032
抄録	Background: In head and neck cancers, histopathological information is important for the determination of the tumor characteristics and for predicting the prognosis. The aim of this study was to assess the utility of diffusion-weighted T2 (DW-T2) mapping for the evaluation of tumor hisinlogical grade in patients with head and neck squamous cell carcinoma (SCC). Methods: The cases of 41 patients with head and neck SCC (21 well/moderately and 17 poorly differentiated SCC) were retrospectively analyzed. All patients received MR scanning using a 3-Tesla MR unit. The conventional T2 value, DW-T2 value, ratio of DW-T2 value to conventional T2 value, and apparent diffusion coefficient (ADC) were calculated using signal information from the DW-T2 mapping sequence with a manually placed region of interest (ROI). Results: ADC values in the poorly differentiated SCC group were significantly lower than those in the moderately/well differentiated SCC group (P<0.05). The ratio of Dvv-T2 value to conventional T2 value was also significantly different between poorly and moderately/well differentiated SCC groups (P<0.01). Receiver operating characteristic (ROC) curve analysis of ADC values showed a sensitivity of 0.76, specificity of 0.67, positive predictive value (PPV) of 0.62, negative predictive value (NPV) of 0.8, accuracy of 0.71 and area under the curve (AUC) of 0.73, whereas the ROC curve analysis of the ratio of DW-T2 value to conventional T2 value showed a sensitivity of 0.76, specificity of 0.83, PPV of 0.76, NPV of 0.83, accuracy of 0.8 and AUC of 0.82. Conclusions: DW-T2 mapping might be useful as supportive information for the determination of tumor histological grade in patients with head and neck SCC.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2223-4292
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.21037/qims-22-136