Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma

Noji, Takehiro; Uemura, Satoko; Wiggers, Jimme K.; Tanaka, Kimitaka; Nakanishi, Yoshitsugu; Asano, Toshimichi; Nakamura, Toru; Tsuchikawa, Takahiro; Okamura, Keisuke; Olthof, Pim B.; Jarnagin, William R.; van Gulik, Thomas M.; Hirano, Satoshi

Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma

Noji, Takehiro; Uemura, Satoko; Wiggers, Jimme K. et al.

Hepatobiliary Surgery and Nutrition, 2022, 11(3), 375-385

Permalink : https://hdl.handle.net/2115/86308

このアイテムのアクセス数:498件（2026-03-15 21:36 集計）

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/86308
タイトル	Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma
著者	Noji, Takehiro ; Uemura, Satoko ; Wiggers, Jimme K. ; Tanaka, Kimitaka ; Nakanishi, Yoshitsugu ; Asano, Toshimichi ; Nakamura, Toru ; Tsuchikawa, Takahiro ; Okamura, Keisuke ; Olthof, Pim B. ; Jarnagin, William R. ; van Gulik, Thomas M. ; Hirano, Satoshi
e-Rad_Researcher 10739296 著者名 Noji, Takehiro
著者名 Uemura, Satoko
著者名 Wiggers, Jimme K.
著者名 Tanaka, Kimitaka
著者名 Nakanishi, Yoshitsugu
著者名 Asano, Toshimichi
著者名 Nakamura, Toru
著者名 Tsuchikawa, Takahiro
著者名 Okamura, Keisuke
著者名 Olthof, Pim B.
著者名 Jarnagin, William R.
著者名 van Gulik, Thomas M.
e-Rad_Researcher 50322813 著者名 Hirano, Satoshi
言語	英語
キーワード	Perihilar cholangiocarcinoma (PHCC)
	post operative mortality score
	post-hepatectomy liver failure score (PHLFS)
	validation study
発行日	2022-06
出版者	AME Publishing Company
収録物名	Hepatobiliary Surgery and Nutrition
巻(号)	11(3)
ページ	375-385
抄録	Background: Surgery for perihilar cholangiocarcinoma (PHCC) remains a challenging procedure with high morbidity and mortality. The Academic Medical Center (Amsterdam UMC) and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score (POMRS) and post-hepatectomy liver failure score (PHLFS) to predict patient outcomes. This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University. Methods: Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS. Results: The observed risks for PHLF were 13.7%, 24.5%, and 39.8% for the low-risk, intermediate risk, and high-risk groups, respectively, in the study cohort. A receiver-operator characteristic (ROC) analysis revealed that the PHLFS had moderate predictive value, with an analysis under the curve (AUC) value of 0.62. Mortality rates based on the POMRS were 1.7%, 5%, and 5.1% for the low-risk, intermediate-risk, and high-risk groups, respectively. The ROC analysis demonstrated an AUC value of 0.58. Conclusions: This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached (AUC >0.6), but it would require optimization of the model before use in clinical practice is acceptable. The POMRS were not applicable in the eastern cohort. Further external validation is recommended.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2304-3881
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.21037/hbsn-20-660