High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia

Senjo, Hajime; Onozawa, Masahiro; Hidaka, Daisuke et al.

Scientific reports, 2022, 12(1), 8885

Permalink : https://hdl.handle.net/2115/86310

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https://doi.org/10.1038/s41598-022-12813-1      

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URI
https://hdl.handle.net/2115/86310
タイトル
High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia
著者
Senjo, Hajime ; Onozawa, Masahiro ; Hidaka, Daisuke ; Yokoyama, Shota ; Yamamoto, Satoshi ; Tsutsumi, Yutaka ; Haseyama, Yoshihito ; Nagashima, Takahiro ; Mori, Akio ; Ota, Shuichi ; Sakai, Hajime ; Ishihara, Toshimichi ; Miyagishima, Takuto ; Kakinoki, Yasutaka ; Kurosawa, Mitsutoshi ; Kobayashi, Hajime ; Iwasaki, Hiroshi ; Hashimoto, Daigo ; Kondo, Takeshi ; Teshima, Takanori
著者名
Senjo, Hajime
著者名
Onozawa, Masahiro
著者名
Hidaka, Daisuke
著者名
Yokoyama, Shota
著者名
Yamamoto, Satoshi
著者名
Tsutsumi, Yutaka
著者名
Haseyama, Yoshihito
著者名
Nagashima, Takahiro
著者名
Mori, Akio
著者名
Ota, Shuichi
著者名
Sakai, Hajime
著者名
Ishihara, Toshimichi
著者名
Miyagishima, Takuto
著者名
Kakinoki, Yasutaka
著者名
Kurosawa, Mitsutoshi
著者名
Kobayashi, Hajime
著者名
Iwasaki, Hiroshi
著者名
Hashimoto, Daigo
著者名
Kondo, Takeshi
e-Rad_Researcher
40284096
著者名
Teshima, Takanori
言語
英語
発行日
2022
出版者
Nature Portfolio
収録物名
Scientific reports
巻(号)
12(1)
ページ
8885
抄録
Acute myeloid leukemia (AML) patients older than 65 years have a poor prognosis. Recently, CAR (C-reactive-protein/albumin ratio) has been actively reported as a prognostic index reflecting the nutritional and inflammatory status of elderly patients with solid tumors, but the usefulness of this index as a prognostic indicator in transplant-ineligible elderly AML patients has not been investigated. We studied genetic alterations and CARs in 188 newly diagnosed AML patients aged 65 years or older who were treated in a multicenter setting and had treated without HSCT. Both NCCN 2017 risk group, reflecting the genetic component of the tumor, and CAR, reflecting the inflammatory and nutritional status of the patient, successfully stratified the overall survival (OS) of the patients (2-year OS; CAR low vs high, 42.3% vs 17.8%, P < 0.001). Furthermore, in multivariate analysis, NCCN 2017 poor group and high CAR were extracted as independent poor prognostic factors predicting 2-year OS in the current study. We found, for the first time, that CAR at diagnosis predicted the prognosis of elderly patients with newly diagnosed AML treated without HSCT.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
2045-2322
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1038/s41598-022-12813-1