open access

https://hdl.handle.net/2115/86420

Proteinous pancreatic lipase inhibitor is responsible for the antiobesity effect of young barley (Hordeum vulgare L.) leaf extract

英語

proteinous lipase inhibitor

2021-08

Oxford University Press

Bioscience biotechnology and biochemistry

85(8)

1885-1889

Young barley leaves (Hordeum vulgare L.) have various health effects and are employed as an ingredient in the production of health-promoting foods. Promoting antiobesity is one such health effect; however, the mechanism and bioactive compounds are unclear. In this research, young barley leaf extract (YB) was demonstrated to possess pancreatic lipase inhibitory activity. The addition of YB to a high-fat diet in mice increased fecal lipid content, indicating reduced absorption of lipids as the mechanism underlying antiobesity effect. The investigation of bioactive compounds in YB resulted in the identification of fructose-bisphosphate aldolase as a proteinous lipase inhibitor. Maximum inhibition of the protein was 45%, but inhibition was displayed at a concentration as low as 16 ng/mL, which is a characteristic inhibition compared with other reported proteinous lipase inhibitors. [GRAPHICS] .

学術雑誌論文

Accepted Manuscript

This is a pre-copyedited, author-produced version of an article accepted for publication in Japan Society for Bioscience, Biotechnology, and Agrochemistry following peer review. The version of record Eisuke Kato, Ai Tsuruma, Ayaka Amishima, Hiroshi Satoh, Proteinous pancreatic lipase inhibitor is responsible for the antiobesity effect of young barley (Hordeum vulgare L.) leaf extract, Bioscience, Biotechnology, and Biochemistry, Volume 85, Issue 8, August 2021, Pages 1885-1889 is available online at: https://doi.org/10.1093/bbb/zbab096.

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