Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand

Rudeeaneksin, Janisara; Phetsuksiri, Benjawan; Nakajima, Chie; Bunchoo, Supranee; Suthum, Krairerk; Tipkrua, Nattakan; Fukushima, Yukari; Suzuki, Yasuhiko

Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand

Rudeeaneksin, Janisara; Phetsuksiri, Benjawan; Nakajima, Chie et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2021, 115(8), 886-895

Permalink : https://hdl.handle.net/2115/86428

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アクセス権	open access
URI	https://hdl.handle.net/2115/86428
タイトル	Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand
著者	Rudeeaneksin, Janisara ; Phetsuksiri, Benjawan ; Nakajima, Chie ; Bunchoo, Supranee ; Suthum, Krairerk ; Tipkrua, Nattakan ; Fukushima, Yukari ; Suzuki, Yasuhiko
著者名 Rudeeaneksin, Janisara
著者名 Phetsuksiri, Benjawan
e-Rad_Researcher 60435964 著者名 Nakajima, Chie
著者名 Bunchoo, Supranee
著者名 Suthum, Krairerk
著者名 Tipkrua, Nattakan
著者名 Fukushima, Yukari
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
言語	英語
キーワード	MIRU-VNTR
	mutation
	outbreak
	spoligotyping
	TB
	Thailand
発行日	2021-08-01
出版者	Oxford University Press
収録物名	Transactions of the Royal Society of Tropical Medicine and Hygiene
巻(号)	115(8)
ページ	886-895
抄録	Background: Multidrug-resistant TB (MDR-TB) outbreaks have occurred in the Thamaka district, Kanchanaburi province in Thailand. Methods: Seventy-two isolates, which included 7% mono-, 30.6% MDR and extensively drug-resistant TB (XDR-TB), were genotyped by spoligotyping, mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR) and single nucleotide polymorphism genotyping, and their drug resistance was analysed. Results: The spoligotyping results showed that Beijing spoligo-international type (SIT)1 was predominant (n=38; 52.8%) while the remaining were non-Beijing sublineages (n=34). The MIRU-VNTR analysis showed that Beijing isolates, most of which belonged to the modern type (n=37), formed 5 clusters and 13 individual patterns. In katG, only mutation Ser315Thr was identified. In rpoB, Ser531Leu was predominant, except for His526Arg and Leu533Pro, which were found in two isolates. A cluster of 14 Beijing strains contained these common mutations and shared the MIRU-VNTR genotype with isolates in the Thamaka district that had spread previously. Two U SIT523 isolates contained the mutations A1400G in rrs and Asp94Gly in gyrA genes, indicating a spread of XDR-TB. Conclusions: Most mutations were associated with drug resistance and the specific MDR Beijing and XDR-TB in U SIT523 isolates remain. This genotyping is a key tool for tracking TB transmission in the Thamaka district of Thailand.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Transactions of the Royal Society of Tropical Medicine and Hygiene following peer review. The version of record is available online at:http://doi.org/10.1093/trstmh/traa148.
PISSN	0035-9203
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/trstmh/traa148