Fecal short-chain fatty acids and obesity in a community-based Japanese population : The DOSANCO Health Study

Yamamura, Ryodai; Nakamura, Koshi; Ukawa, Shigekazu; Okada, Emiko; Nakagawa, Takafumi; Imae, Akihiro; Kunihiro, Tadao; Kimura, Takashi; Hirata, Takumi; Tamakoshi, Akiko

Fecal short-chain fatty acids and obesity in a community-based Japanese population : The DOSANCO Health Study

Yamamura, Ryodai; Nakamura, Koshi; Ukawa, Shigekazu et al.

Obesity Research & Clinical Practice, 2021, 15(4), 345-350

Permalink : https://hdl.handle.net/2115/86444

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アクセス権	open access
URI	https://hdl.handle.net/2115/86444
タイトル	Fecal short-chain fatty acids and obesity in a community-based Japanese population : The DOSANCO Health Study
著者	Yamamura, Ryodai ; Nakamura, Koshi ; Ukawa, Shigekazu ; Okada, Emiko ; Nakagawa, Takafumi ; Imae, Akihiro ; Kunihiro, Tadao ; Kimura, Takashi ; Hirata, Takumi ; Tamakoshi, Akiko
e-Rad_Researcher 40880000 著者名 Yamamura, Ryodai
e-Rad_Researcher 80422898 著者名 Nakamura, Koshi
著者名 Ukawa, Shigekazu
著者名 Okada, Emiko
著者名 Nakagawa, Takafumi
著者名 Imae, Akihiro
著者名 Kunihiro, Tadao
著者名 Kimura, Takashi
著者名 Hirata, Takumi
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	Fecal short-chain fatty acids
	Obesity
	Epidemiology
	Japanese
発行日	2021-07
出版者	Elsevier
収録物名	Obesity Research & Clinical Practice
巻(号)	15(4)
ページ	345-350
抄録	In Western populations, fecal concentrations of short-chain fatty acids (SCFAs) are positively correlated with the prevalence of obesity. However, gut microbiota involved in the production of SCFA varies between races. Our purpose was to investigate the associations between fecal SCFAs and the prevalence of obesity in a community-based Japanese population. We classified a total of 568 participants aged >= 18 into four quartiles of fecal concentrations of SCFA subtypes (acetate, butyrate, and propionate) and total SCFAs to compare the prevalence of obesity, defined as a body mass index >= 25.0 kg/m(2). Using the first quartile SCFA group as a reference, the prevalence ratios of obesity were calculated for each SCFA group through a log-binomial regression model adjusted for major potentially confounding factors including age, sex, exercise habits, total energy intake, and total dietary fiber intake. In the study population, the prevalence of obesity was 35.8%. The prevalence ratios (95% confidence intervals) of obesity in the second, third, and fourth quartile groups of fecal total SCFAs were 1.30 (0.89-1.89), 1.74 (1.23-2.47) and 1.70 (1.19-2.41), respectively, after adjusting for the confounders. Similar positive associations were observed for every subtype. The prevalence ratios (95% confidence intervals) in the fourth quartile groups of fecal acetate, butyrate, and propionate were 1.41 (1.02-1.97), 2.16 (1.49-3.14), and 1.97 (1.35-2.89), respectively, after adjusting for the confounders. In conclusion, our results demonstrated that fecal SCFA concentrations of every subtype were positively associated with the prevalence of obesity in a community-based Japanese population.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1871-403X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.orcp.2021.06.003