Evaluation of Right Ventricular Function and Dyssynchrony in a Dog Model of Acute Pulmonary Embolism : Diagnostic Utility and Reversibility

Morita, Tomoya; Nakamura, Kensuke; Osuga, Tatsuyuki; Kawamoto, Sei; Miki, Shingo; Takiguchi, Mitsuyoshi

Evaluation of Right Ventricular Function and Dyssynchrony in a Dog Model of Acute Pulmonary Embolism : Diagnostic Utility and Reversibility

Morita, Tomoya; Nakamura, Kensuke; Osuga, Tatsuyuki et al.

Frontiers in veterinary science, 2022, 9, 861064

Permalink : https://hdl.handle.net/2115/86507

このアイテムのアクセス数:454件（2026-01-15 12:15 集計）

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https://doi.org/10.3389/fvets.2022.861064

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/86507
タイトル	Evaluation of Right Ventricular Function and Dyssynchrony in a Dog Model of Acute Pulmonary Embolism : Diagnostic Utility and Reversibility
著者	Morita, Tomoya ; Nakamura, Kensuke ; Osuga, Tatsuyuki ; Kawamoto, Sei ; Miki, Shingo ; Takiguchi, Mitsuyoshi
著者名 Morita, Tomoya
e-Rad_Researcher 80625898 著者名 Nakamura, Kensuke
著者名 Osuga, Tatsuyuki
著者名 Kawamoto, Sei
著者名 Miki, Shingo
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
言語	英語
キーワード	pulmonary hypertension
	microsphere injection
	speckle tracking echocardiography
	Tei index
	cardiac catheterization
発行日	2022-06-20
出版者	Frontiers Media
収録物名	Frontiers in veterinary science
巻(号)	9
ページ	861064
抄録	Background: The diagnosis of acute pulmonary thromboembolism is challenging in dogs. Little has been reported on changes in echocardiographic indices in dogs with acute pulmonary thromboembolism. The objective of this study was to validate the relationship between echocardiographic indices and right heart catheterization variables in dogs with acute pulmonary embolism and to identify a useful echocardiographic index for diagnosing acute pulmonary embolism. Materials and Methods: Six healthy laboratory beagles were included in the study. Echocardiography and right heart catheterization were performed in a dog model of acute pulmonary embolism produced by microsphere injection. Echocardiographic indices, including the right ventricular (RV) Tei index, RV longitudinal strain, and the dyssynchrony index using speckle tracking echocardiography, transmitral flow, and eccentricity index, were measured. Results: The mean pulmonary arterial pressure increased (22.2 +/- 1.2 mmHg) and the blood pressure decreased after microsphere injection. Although the mean pulmonary arterial pressure remained elevated, the blood pressure recovered 2 days after the microsphere injection. Most echocardiographic indices of RV function were significantly impaired following microsphere injection and recovered after 2 days. In contrast, the RV Tei index was significantly impaired after microsphere injection and the impairment persisted after 2 days. Multivariable analysis revealed that the RV Tei index was an independent echocardiographic predictor of pulmonary vascular resistance (beta = 0.88, P < 0.001), and transmitral early diastolic wave was an independent predictor of the cardiac index (beta = -0.86, P = 0.001). Conclusions: The RV Tei index is a useful echocardiographic index for diagnosing acute pulmonary embolism. Ventricular interdependence may be an important factor causing low cardiac output in dogs with acute pulmonary embolism.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	2297-1769
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3389/fvets.2022.861064