Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia

Yohannes, Yared Beyene; Nakayama, Shouta M. M.; Yabe, John; Toyomaki, Haruya; Kataba, Andrew; Nakata, Hokuto; Muzandu, Kaampwe; Ikenaka, Yoshinori; Choongo, Kennedy; Ishizuka, Mayumi

Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia

Yohannes, Yared Beyene; Nakayama, Shouta M. M.; Yabe, John et al.

Environmental science and pollution research, 2021, 29(5), 6622-6632

Permalink : https://hdl.handle.net/2115/86627

このアイテムのアクセス数:456件（2026-03-04 23:24 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
ESPR-D-21-08222-Revise	pdf	1.00 MB	434
Supplemtary material	docx	28.7 KB	113	Supplemtary material

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/86627
タイトル	Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia
著者	Yohannes, Yared Beyene ; Nakayama, Shouta M. M. ; Yabe, John ; Toyomaki, Haruya ; Kataba, Andrew ; Nakata, Hokuto ; Muzandu, Kaampwe ; Ikenaka, Yoshinori ; Choongo, Kennedy ; Ishizuka, Mayumi
著者名 Yohannes, Yared Beyene
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
著者名 Yabe, John
著者名 Toyomaki, Haruya
著者名 Kataba, Andrew
e-Rad_Researcher 60815273 著者名 Nakata, Hokuto
著者名 Muzandu, Kaampwe
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
著者名 Choongo, Kennedy
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	Blood
	Children
	Lead
	Cadmium
	GST
	Polymorphism
	Kabwe
発行日	2021-08-28
出版者	Springer
収録物名	Environmental science and pollution research
巻(号)	29(5)
ページ	6622-6632
抄録	Interindividual genetic variations determine human's susceptibility to heavy metal-induced toxicity. Thus, we analyzed blood concentrations of lead (Pb) and cadmium (Cd) in 140 lead-exposed children. Genotyping of the glutathione S-transferase (GST) genes, GSTM1, GSTT1, and GSTP1 genes, was carried out to investigate their possible association with heavy metal concentrations and the risk of susceptibility to Pb toxicity. Exposure to both heavy metals was prevalent among the children. The blood Pb level ranged from 3.30 to 74.0 mu g dL(-1) with an average value of 26.8 mu g dL(-1) that is five times above its reference level. The average Cd level (0.22 mu g L-1) was below its reference level. The metal-gene interaction showed positive correlation between GSTT1 null genotype and Pb and Cd levels (beta = 0.11; p = 0.02 and beta = 0.10; p = 0.01, respectively). More pronounced effects (beta = 0.19; p < 0.01 and beta = 0.25; p = 0.04) were found for the mixture of the three putative genes with blood Pb concentration. The susceptibility analysis using 10 mu g dL(-1) as blood Pb cutoff level showed a high risk of Pb toxicity (OR = 2.54; 95% CI: 1.02-6.32, p = 0.04) for children carrying the GSTP1 Ile/Val genotype. Further, the combined effect of GSTP1 Ile/Val with GSTT1 null genotype was more pronounced and showed an increased risk of susceptibility to Pb toxicity (OR = 11.7; 95% CI: 1.36-102.1, p = 0.02). In summary, this study suggests that GSTT1 null and GSTP1 Ile/Val genotypes are the main genetic factors, and individual and specific combinations of GSTP1 Ile/Val with GSTM1 and GSTT1 GST polymorphisms are associated with susceptibility to Pb toxicity.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11356-021-16098-1
PISSN	0944-1344
EISSN	1614-7499
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11356-021-16098-1