Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds

NAGATA, Noriyuki; OHTA, Hiroshi; YOKOYAMA, Nozomu et al.

Journal of veterinary medical science, 2022, 84(6), 872-876

Permalink : https://hdl.handle.net/2115/86653

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https://doi.org/10.1292/jvms.22-0076     18

論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/86653
タイトル
Characterization of mucin gene expression and goblet cell proportion in inflammatory colorectal polyps in miniature dachshunds
著者
NAGATA, Noriyuki ; OHTA, Hiroshi ; YOKOYAMA, Nozomu ; Bin TEOH, Yong ; SASAKI, Noboru ; NAKAMURA, Kensuke ; TAKIGUCHI, Mitsuyoshi
著者名
NAGATA, Noriyuki
著者名
OHTA, Hiroshi
著者名
YOKOYAMA, Nozomu
著者名
Bin TEOH, Yong
e-Rad_Researcher
00754532
著者名
SASAKI, Noboru
e-Rad_Researcher
80625898
著者名
NAKAMURA, Kensuke
e-Rad_Researcher
70261336
著者名
TAKIGUCHI, Mitsuyoshi
言語
英語
キーワード
canine
goblet cell
inflammatory colorectal polyp
mucin
発行日
2022-06-18
出版者
公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名
Journal of veterinary medical science
巻(号)
84(6)
ページ
872-876
抄録
Hyperplastic goblet cells and abundant mucus are significant characteristics of inflammatory colorectal polyps (ICRPs) in miniature dachshunds. In this study, selected mucin gene expressions and goblet cell proportions were evaluated in miniature dachshunds with ICRPs and in healthy dogs. Mucin 2 (MUC2) gene expression was not significantly different among the groups, whereas mucin 5AC (MUC5AC) gene expression was significantly higher in the polypoid lesions than in healthy colonic mucosa. Although the percentage of goblet cells in the upper crypt regions did not significantly differ between the groups, that in the lower crypt regions was significantly decreased in polypoid lesions. In conclusion, increased MUC5AC gene expression and goblet cell proportion changes may be associated with the pathogenesis of ICRPs.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0916-7250
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1292/jvms.22-0076