First Report of a Complete Genome Sequence of a Variant African Swine Fever Virus in the Mekong Delta, Vietnam

Hien, Nguyen Duc; Nguyen, Lam Thanh; Hoang, Le Trung; Bich, Nguyen Ngoc; Quyen, To My; Isoda, Norikazu; Sakoda, Yoshihiro

First Report of a Complete Genome Sequence of a Variant African Swine Fever Virus in the Mekong Delta, Vietnam

Hien, Nguyen Duc; Nguyen, Lam Thanh; Hoang, Le Trung et al.

Pathogens, 2022, 11(7), 797

Permalink : https://hdl.handle.net/2115/86656

このアイテムのアクセス数:369件（2026-03-15 20:33 集計）

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論文情報

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/86656
タイトル	First Report of a Complete Genome Sequence of a Variant African Swine Fever Virus in the Mekong Delta, Vietnam
著者	Hien, Nguyen Duc ; Nguyen, Lam Thanh ; Hoang, Le Trung ; Bich, Nguyen Ngoc ; Quyen, To My ; Isoda, Norikazu ; Sakoda, Yoshihiro
著者名 Hien, Nguyen Duc
著者名 Nguyen, Lam Thanh
著者名 Hoang, Le Trung
著者名 Bich, Nguyen Ngoc
著者名 Quyen, To My
e-Rad_Researcher 80615732 著者名 Isoda, Norikazu
e-Rad_Researcher 40333637 著者名 Sakoda, Yoshihiro
言語	英語
キーワード	African swine fever
	complete genome
	Mekong Delta
	variant
	Vietnam
発行日	2022-07-15
出版者	MDPI
収録物名	Pathogens
巻(号)	11(7)
ページ	797
抄録	The objective of this study is to report the complete-genome sequence of a field African swine fever (ASF) virus (ASFV), namely ASF/VN/CanTho-OM/2021, which caused a fatal outbreak in domestic pigs in the Mekong Delta. Complete-genome sequencing detected an 18 bp nucleotide deletion in the EP402R gene (encoding for serotype-specific proteins CD2v) of ASF/VN/CanTho-OM/2021, which was determined to belong to genotype 2 and serotype 8. This mutation pattern was confirmed as unique in GenBank; thus, ASF/VN/CanTho-OM/2021 can be considered a novel variant, with a potential change of sero-characteristics within genotype 2. An additional unique mutation of 78 bp nucleotide insertion was also observed in the B475L gene. Additionally, four copies of tandem repeat sequences were found in the intergenic region (IGR) located between I73R and I329L, previously assigned as the IGR III variant. This study is the first to report the complete genome of ASFV in the Mekong Delta, and it highlights the necessity of strengthening molecular surveillance to provide further knowledge on the evolution and incursion of ASFV in the Mekong Delta and Vietnam.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2076-0817
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/pathogens11070797