Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens

Ishii, Chihiro; Kawai, Yusuke K.; Ikenaka, Yoshinori; Maekawa, Naoya; Ichii, Osamu; Nakayama, Shouta M. M.; Ishizuka, Mayumi

Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens

Ishii, Chihiro; Kawai, Yusuke K.; Ikenaka, Yoshinori et al.

Poultry Science, 2022, 101(9), 102011

Permalink : https://hdl.handle.net/2115/86666

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/86666
タイトル	Clarifying expression patterns by renal lesion using transcriptome analysis and vanin-1 as a potential novel biomarker for renal injury in chickens
著者	Ishii, Chihiro ; Kawai, Yusuke K. ; Ikenaka, Yoshinori ; Maekawa, Naoya ; Ichii, Osamu ; Nakayama, Shouta M. M. ; Ishizuka, Mayumi
著者名 Ishii, Chihiro
著者名 Kawai, Yusuke K.
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 70829035 著者名 Maekawa, Naoya
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
e-Rad_Researcher 90647629 著者名 Nakayama, Shouta M. M.
e-Rad_Researcher 50332474 著者名 Ishizuka, Mayumi
言語	英語
キーワード	acute interstitial nephritis (AIN)
	acute tubular necrosis (ATN)
	bird
	VNN1 (vanin-1)
	renal biomarker
発行日	2022-09
出版者	Elsevier
収録物名	Poultry Science
巻(号)	101(9)
ページ	102011
抄録	Bird death is often caused by renal lesions induced by chemicals. The avian kidney has a renal portal system with significant blood flow that is sensitive to many chemicals. However, early avian bio-markers for kidney injury are yet to be identified. This study aimed to identify novel renal biomarkers. Acute kidney injury (AKI) can be divided into acute intersti-tial nephritis (AIN) and acute tubular necrosis (ATN). A chicken model of kidney damage was created by an injection of diclofenac or cisplatin, which caused either AIN or ATN, respectively. Microarray analysis was per-formed to profile the gene expression patterns in the chickens with nephropathy. A gene enrichment analysis suggested that the genes related to responses to external stimuli showed expression changes in both AIN and ATN. However, hierarchical clustering analyses sug-gested that gene expression patterns differed between AIN and ATN, and the number of biomarkers relating to renal damage was low. To identify early biomarkers for nephropathy, we focused on genes that were induced at various levels of renal damage. The gene, vanin-1 (VNN1) was highly induced in the early stages of renal damage. A quantitative real-time PCR analysis sup-ported this finding. These results suggest VNN1 could be a useful early biomarker of kidney injury in avian species.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0032-5791
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1016/j.psj.2022.102011