Taste 2 Receptor Is Involved in Differentiation of 3T3-L1 Preadipocytes

Kimura, Shunsuke; Tsuruma, Ai; Kato, Eisuke

International Journal of Molecular Sciences, 2022, 23(15), 8120

Permalink : https://hdl.handle.net/2115/86745

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https://doi.org/10.3390/ijms23158120     145

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アクセス権
open access
URI
https://hdl.handle.net/2115/86745
タイトル
Taste 2 Receptor Is Involved in Differentiation of 3T3-L1 Preadipocytes
著者
Kimura, Shunsuke ; Tsuruma, Ai ; Kato, Eisuke
著者名
Kimura, Shunsuke
著者名
Tsuruma, Ai
e-Rad_Researcher
40466446
著者名
Kato, Eisuke
言語
英語
キーワード
taste 2 receptor
bitter taste receptor
epicatechin
differentiation
lipid accumulation
発行日
2022-08
出版者
MDPI
収録物名
International Journal of Molecular Sciences
巻(号)
23(15)
ページ
8120
抄録
Expression of taste 2 receptor (T2R) genes, also known as bitter taste receptor genes, has been reported in a variety of tissues. The white adipose tissue of mice has been shown to express Tas2r108, Tas2r126, Tas2r135, Tas2r137, and Tas2r143, but the function of T2Rs in adipocytes remains unclear. Here, we show that fasting and stimulation by bitter compounds both increased Tas2r expression in mouse white adipose tissue, and serum starvation and stimulation by bitter compounds both increased the expression of Tas2r genes in 3T3-L1 adipocytes, suggesting that T2Rs have functional roles in adipocytes. RNA sequencing analysis of 3T3-L1 adipocytes stimulated by epicatechin, the ligand of Tas2r126, suggested that this receptor may play a role in the differentiation of adipocytes. Overexpression of Tas2r126 in 3T3-L1 preadipocytes decreases fat accumulation after induction of differentiation and reduces the expression of adipogenic genes. Together, these results indicate that Tas2r126 may be involved in adipocyte differentiation.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.3390/ijms23158120