Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

Takeda, Ryo; Sawa, Hirofumi; Sasaki, Michihito; Orba, Yasuko; Maishi, Nako; Tsumita, Takuya; Ushijima, Natsumi; Hida, Yasuhiro; Sano, Hidehiko; Kitagawa, Yoshimasa; Hida, Kyoko

Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

Takeda, Ryo; Sawa, Hirofumi; Sasaki, Michihito et al.

Scientific reports, 2022, 12(1), 14050

Permalink : https://hdl.handle.net/2115/86766

このアイテムのアクセス数:391件（2026-01-25 11:55 集計）

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https://doi.org/10.1038/s41598-022-18367-6

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/86766
タイトル	Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2
著者	Takeda, Ryo ; Sawa, Hirofumi ; Sasaki, Michihito ; Orba, Yasuko ; Maishi, Nako ; Tsumita, Takuya ; Ushijima, Natsumi ; Hida, Yasuhiro ; Sano, Hidehiko ; Kitagawa, Yoshimasa ; Hida, Kyoko
e-Rad_Researcher 90645095 著者名 Takeda, Ryo
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
e-Rad_Researcher 70609403 著者名 Sasaki, Michihito
e-Rad_Researcher 60507169 著者名 Orba, Yasuko
e-Rad_Researcher 00632423 著者名 Maishi, Nako
著者名 Tsumita, Takuya
e-Rad_Researcher 40374558 著者名 Ushijima, Natsumi
e-Rad_Researcher 30399919 著者名 Hida, Yasuhiro
e-Rad_Researcher 90205998 著者名 Sano, Hidehiko
e-Rad_Researcher 00224957 著者名 Kitagawa, Yoshimasa
e-Rad_Researcher 40399952 著者名 Hida, Kyoko
言語	英語
発行日	2022-08-18
出版者	Nature Portfolio
収録物名	Scientific reports
巻(号)	12(1)
ページ	14050
抄録	Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports on the effect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 mu g/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 effects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	2045-2322
関連情報	PMID 35982118
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-022-18367-6