Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy

Yamashita, Yui; Hashimoto, Yuki; Namba, Kenichi; Mizuuchi, Kazuomi; Ishida, Susumu

Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy

Yamashita, Yui; Hashimoto, Yuki; Namba, Kenichi et al.

Case reports in ophthalmology, 2021, 12(3), 899-908

Permalink : https://hdl.handle.net/2115/86789

このアイテムのアクセス数:273件（2026-01-24 10:44 集計）

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https://doi.org/10.1159/000520036

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/86789
タイトル	Optic Nerve Head Microcirculation in Eyes with Vogt-Koyanagi-Harada Disease Accompanied by Anterior Ischemic Optic Neuropathy
著者	Yamashita, Yui ; Hashimoto, Yuki ; Namba, Kenichi ; Mizuuchi, Kazuomi ; Ishida, Susumu
著者名 Yamashita, Yui
著者名 Hashimoto, Yuki
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
著者名 Mizuuchi, Kazuomi
e-Rad_Researcher 10245558 著者名 Ishida, Susumu
言語	英語
キーワード	Anterior ischemic optic neuropathy
	Laser speckle flowgraphy
	Optical coherence tomography
	Optic nerve head microcirculation
	Vogt-Koyanagi-Harada disease
発行日	2021-09
出版者	Karger
収録物名	Case reports in ophthalmology
巻(号)	12(3)
ページ	899-908
抄録	Anterior ischemic optic neuropathy (AION) is infrequently complicated with Vogt-Koyanagi-Harada (VKH) disease. We quantitatively examined sequential changes in the morphology and circulation hemodynamics, using a C-scan of optical coherence tomography (OCT) and laser speckle flowgraphy (LSFG) in a patient with VKH disease accompanied by AION. A 65-year-old female complained of blurred vision in both of her eyes. The patient presented with optic disc swelling and remarkable choroidal thickening detected by OCT bilaterally. The diagnosis of VKH disease was established based on the presence of pleocytosis detected in the cerebrospinal fluid and hypofluorescent dark dots scattered all around the fundus, detected by indocyanine green angiography. Goldmann perimetry detected visual field defects, similar to superior altitudinal hemianopsia in the right eye and similar to inferior altitudinal hemianopsia in the left eye. The patient was suspected to have developed AION in both eyes. The patient received methylprednisolone pulse therapy, followed by oral prednisolone. With these treatments, the optic disc swelling disappeared. However, optic disc atrophy with visual field defects remained in both eyes. An OCT C-scan showed the ganglion cell complex (GCC) and circumpapillary retinal nerve fiber layer (cpRNFL) thickness getting thinner below the normal range, and LSFG showed the decrease in optic nerve head (ONH) tissue microcirculation. These results supported the occurrence of AION in this patient with VKH disease. The analysis of GCC and cpRNFL thickness and ONH microcirculation would be useful for supporting the occurrence of AION in a case of VKH disease. (C) 2021 The Author(s). Published by S. Karger AG, Basel
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1663-2699
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1159/000520036