Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task

Wakatsuki, Yumi; Ogura, Yukiko; Hashimoto, Naoki; Toyomaki, Atsuhito; Miyamoto, Tamaki; Nakagawa, Shin; Inoue, Takeshi; Kusumi, Ichiro

Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task

Wakatsuki, Yumi; Ogura, Yukiko; Hashimoto, Naoki et al.

Psychiatry and clinical neurosciences, 2022, 76(8), 393-400

Permalink : https://hdl.handle.net/2115/86793

このアイテムのアクセス数:359件（2026-08-10 16:40 集計）

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https://doi.org/10.1111/pcn.13429			113

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アクセス権	open access
URI	https://hdl.handle.net/2115/86793
タイトル	Subjects with bipolar disorder showed different reward system activation than subjects with major depressive disorder in the monetary incentive delay task
著者	Wakatsuki, Yumi ; Ogura, Yukiko ; Hashimoto, Naoki ; Toyomaki, Atsuhito ; Miyamoto, Tamaki ; Nakagawa, Shin ; Inoue, Takeshi ; Kusumi, Ichiro
著者名 Wakatsuki, Yumi
著者名 Ogura, Yukiko
著者名 Hashimoto, Naoki
著者名 Toyomaki, Atsuhito
著者名 Miyamoto, Tamaki
著者名 Nakagawa, Shin
著者名 Inoue, Takeshi
e-Rad_Researcher 30250426 著者名 Kusumi, Ichiro
言語	英語
キーワード	anterior insula
	bipolar disorder
	functional MRI
	major depressive disorder
	monetary incentive delay
発行日	2022-08
出版者	John Wiley & Sons
収録物名	Psychiatry and clinical neurosciences
巻(号)	76(8)
ページ	393-400
抄録	Background Differentiating between bipolar disorder (BD) and major depressive disorder (MDD) during the depressive episode is an important clinical challenge. Reward system abnormalities have received much attention as one of the biological underpinnings of BD and MDD, but few studies have directly compared these abnormalities in remitted and depressed states. Methods This was a functional MRI study using the Monetary Incentive Delay task in 65 patients (BD [n = 33], MDD [n = 32]) and 33 healthy controls (HC). Regions of interest (ROI) analysis with 21 ROIs related to reward anticipation and 17 ROIs related to gain outcome were implemented, as well as whole-brain analysis. The difference in the dimensional effect of depression on brain activation was also examined. Results Relative to the HC group, BD patients showed significantly decreased activation during reward anticipation in the anterior cingulate cortex, anterior insula (AI), and putamen, and MDD patients showed significantly decreased activation in the AI and brainstem. The dimensional effect of depression severity showed a trend-level difference between BD and MDD in the right brainstem and left AI. Conclusions The current study showed a possible differential effect of depression on the reward system between MDD and BD. Further studies on reward systems might offer reliable markers to distinguish between MDD and BD patients in the depressive phase.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1323-1316
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/pcn.13429