IFN-α/β-mediated NK2R expression is related to the malignancy of colon cancer cells

Xiang, Huihui; Toyoshima, Yujiro; Shen, Weidong; Wang, Xiangdong; Okada, Naoki; Kii, Shuhei; Sugiyama, Ko; Nagato, Toshihiro; Kobayashi, Hiroya; Ikeo, Kazuho; Hashimoto, Shinichi; Tanino, Mishie; Taketomi, Akinobu; Kitamura, Hidemitsu

IFN-α/β-mediated NK2R expression is related to the malignancy of colon cancer cells

Xiang, Huihui; Toyoshima, Yujiro; Shen, Weidong et al.

Cancer Science, 2022, 113(8), 2513-2525

Permalink : https://hdl.handle.net/2115/86872

このアイテムのアクセス数:398件（2026-08-24 20:56 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/86872
タイトル	IFN-α/β-mediated NK2R expression is related to the malignancy of colon cancer cells
著者	Xiang, Huihui ; Toyoshima, Yujiro ; Shen, Weidong ; Wang, Xiangdong ; Okada, Naoki ; Kii, Shuhei ; Sugiyama, Ko ; Nagato, Toshihiro ; Kobayashi, Hiroya ; Ikeo, Kazuho ; Hashimoto, Shinichi ; Tanino, Mishie ; Taketomi, Akinobu ; Kitamura, Hidemitsu
著者名 Xiang, Huihui
著者名 Toyoshima, Yujiro
著者名 Shen, Weidong
著者名 Wang, Xiangdong
著者名 Okada, Naoki
著者名 Kii, Shuhei
著者名 Sugiyama, Ko
著者名 Nagato, Toshihiro
著者名 Kobayashi, Hiroya
著者名 Ikeo, Kazuho
著者名 Hashimoto, Shinichi
著者名 Tanino, Mishie
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
e-Rad_Researcher 40360531 著者名 Kitamura, Hidemitsu
言語	英語
キーワード	colon cancer
	JAK
	malignancy
	neurokinin-2 receptor
	type I IFN
発行日	2022-08
出版者	Wiley
収録物名	Cancer Science
巻(号)	113(8)
ページ	2513-2525
抄録	Neurokinin 2 receptor (NK2R), a G protein-coupled receptor for neurokinin A (NKA), a tachykinin family member, regulates various physiological functions including pain response, relaxation of smooth muscle, dilation of blood vessels, and vascular permeability. However, the precise role and regulation of NK2R expression in cancer cells have not been fully elucidated. In this study, we found that high NK2R gene expression was correlated with the poor survival of colorectal cancer patients, and Interferon (IFN-α/β) stimulation significantly enhanced NK2R gene expression level of colon cancer cells in a Janus kinas 1/2 (JAK 1/2)-dependent manner. NKA stimulation augmented viability/proliferation and phosphorylation of Extracellular-signal-regulated kinase 1/2 (ERK1/2) levels of IFN-α/β-treated colon cancer cells and NK2R blockade by using a selective antagonist reduced the proliferation in vitro. Administration of an NK2R antagonist alone or combined with polyinosinic-polycytidylic acid, a synthetic analog of double-stranded RNA, to CT26-bearing mice significantly suppressed tumorigenesis. NK2R-overexpressing CT26 cells showed enhanced tumorigenesis and metastatic colonization in both lung and liver after the inoculation into mice. These findings indicate that IFN-α/β-mediated NK2R expression is related to the malignancy of colon cancer cells, suggesting that NK2R blockade may be a promising strategy for colon cancers.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	1347-9032
EISSN	1349-7006
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/cas.15397