Central Hepatectomy Versus Major Hepatectomy for Centrally Located Hepatocellular Carcinoma : A Propensity Score Matching Study

Orimo, Tatsuya; Kamiyama, Toshiya; Kakisaka, Tatsuhiko et al.

Annals of surgical oncology, 2021, 28, 6769-6779

Permalink : https://hdl.handle.net/2115/86880

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アクセス権
open access
URI
https://hdl.handle.net/2115/86880
タイトル
Central Hepatectomy Versus Major Hepatectomy for Centrally Located Hepatocellular Carcinoma : A Propensity Score Matching Study
著者
Orimo, Tatsuya ; Kamiyama, Toshiya ; Kakisaka, Tatsuhiko ; Shimada, Shingo ; Nagatsu, Akihisa ; Asahi, Yoh ; Sakamoto, Yuzuru ; Kamachi, Hirofumi ; Taketomi, Akinobu
e-Rad_Researcher
80711861
著者名
Orimo, Tatsuya
著者名
Kamiyama, Toshiya
著者名
Kakisaka, Tatsuhiko
著者名
Shimada, Shingo
著者名
Nagatsu, Akihisa
著者名
Asahi, Yoh
著者名
Sakamoto, Yuzuru
著者名
Kamachi, Hirofumi
e-Rad_Researcher
70363364
著者名
Taketomi, Akinobu
言語
英語
発行日
2021-10-01
出版者
Springer
収録物名
Annals of surgical oncology
巻(号)
28
ページ
6769-6779
抄録
Background In terms of anatomical liver sectionectomy approaches, both a central hepatectomy (CH) and major hepatectomy (MH) are feasible options for a centrally located hepatocellular carcinoma (HCC). Methods We retrospectively reviewed the surgical outcomes of central HCC patients who underwent CH or MH. MH includes hemihepatectomy or trisectionectomy, whereas CH involves a left medial sectionectomy, right anterior sectionectomy, or central bisectionectomy. The surgical outcomes were compared before and after propensity score matching (PSM). Results A total of 233 patients were enrolled, including 132 in the CH group and 101 in the MH group. The MH group cases were pathologically more advanced and had poorer overall survival rates than the CH group. After PSM, 68 patients were selected into each group, both of which showed similar overall and recurrence-free survival outcomes. The CH group showed a tendency for a longer operation time; however, other perioperative outcomes were similar between the two groups. Multivariate analyses of our matched HCC patients revealed that the type of surgery (CH or MH) was not an independent prognostic factor. More patients in the matched CH group experienced a repeat hepatectomy for recurrence and no patients in this group underwent a preoperative portal vein embolization. Conclusions The short- and long-term surgical outcomes of CH and MH for a centrally located HCC are similar under a matched clinicopathological background. CH has the advantage of not requiring a preoperative portal vein embolization and increased chances of conducting a repeat hepatectomy for recurrence.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is a post-peer-review, pre-copyedit version of an article published in Annals of Surgical Oncology. The final authenticated version is available online at: http://dx.doi.org/10.1245/s10434-021-09751-z
PISSN
1068-9265
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1245/s10434-021-09751-z