Functional analysis of OCIAD2 in hepatoblastoma

Minato, M.; Honda, S.; Miyagi, H. et al.

Genetics and Molecular Research, 2022, 21(1), gmr19006

Permalink : https://hdl.handle.net/2115/86938

このアイテムのアクセス数:394件（2026-08-12 03:20 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
https://doi.org/10.4238/gmr19006     14

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/86938
タイトル
Functional analysis of OCIAD2 in hepatoblastoma
著者
Minato, M. ; Honda, S. ; Miyagi, H. ; Taketomi, A.
著者名
Minato, M.
著者名
Honda, S.
著者名
Miyagi, H.
e-Rad_Researcher
70363364
著者名
Taketomi, A.
言語
英語
キーワード
Hepatoblastoma
Epigenomics
OCIA domain containing
DNA methylation
Oncology
発行日
2022-02-27
出版者
Funpec Editora
収録物名
Genetics and Molecular Research
巻(号)
21(1)
ページ
gmr19006
抄録
Hepatoblastoma (HB) is the most common malignant liver tumor in children; however, the molecular mechanisms responsible for its progression remain unclear. We previously identified hypermethylation of the ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) as a poor prognostic factor for HB in a genome-wide methylation analysis of HB excision specimens. As it has been already reported that such hypermethylation of OCIAD2 dysregulates the expression of OCIAD2, to elucidate the function of OCIAD2 in HB, we evaluated altered cellular functions such as cell growth, invasion, and migration abilities using OCIAD2 overexpression cell lines of HB. In the in vitro analysis with OCIAD2 overexpression, no significant difference was observed in cell proliferation between the groups. However, migration and invasion abilities were significantly lower in OCIAD2 overexpressed cell lines. Second, overexpression of OCIAD2 reduced matrix metalloproteinase 2 (MMP2) levels in each cell line. These results suggest that OCIAD2 suppresses HB invasion and migration in relation to MMP2.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.4238/gmr19006