Classification of Marine Algae-Derived Compounds by the Mechanism Responsible for Decreasing Lipoxygenase-Catalyzed Lipid Hydroperoxides

Kurihara, Hideyuki; Yachiyama, Kenta; Morimoto, Chihiro

Classification of Marine Algae-Derived Compounds by the Mechanism Responsible for Decreasing Lipoxygenase-Catalyzed Lipid Hydroperoxides

Kurihara, Hideyuki; Yachiyama, Kenta; Morimoto, Chihiro

Natural product communications, 2022, 17(8), 1934578X221115249

Permalink : https://hdl.handle.net/2115/86947

このアイテムのアクセス数:338件（2026-01-24 05:26 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1177/1934578X221115249

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	metadata only access
URI	https://hdl.handle.net/2115/86947
タイトル	Classification of Marine Algae-Derived Compounds by the Mechanism Responsible for Decreasing Lipoxygenase-Catalyzed Lipid Hydroperoxides
著者	Kurihara, Hideyuki ; Yachiyama, Kenta ; Morimoto, Chihiro
e-Rad_Researcher 40234570 著者名 Kurihara, Hideyuki
著者名 Yachiyama, Kenta
著者名 Morimoto, Chihiro
言語	英語
キーワード	phenolics
	fucoxanthin
	pheophytin a
	lipoxygenase
	inhibitor
	lipid hydroperoxide
	decomposer marine natural products
	structure
	biosynthesis
	biological activities
	synthetic derivatives and analogs
	short communication
発行日	2022-08
出版者	SAGE Publications
収録物名	Natural product communications
巻(号)	17(8)
ページ	1934578X221115249
抄録	Lipoxygenase (LOX)-mediated lipid hydroperoxides (LHPOs) are converted to physiologically active mediators. Thus, decreasing hydroperoxides is important for diminishing various health-related risks. In this study, decreasing compounds of LOX-catalyzed LHPOs were investigated and classified by mechanism using a modified triple LOX-indamine dye formation (IDF) method. The compounds 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1) and fucoxanthin (2) were isolated from algae as compounds that can decrease hydroperoxides. Along with previously isolated pheophytin a (3), a chlorophyll-related compound, and purchased nordihydroguaiaretic acid (4), a well-known lipoxygenase inhibitor, all the compounds were examined to determine the mechanisms responsible for decreasing LHPOs by using a modified triple LOX-IDF method. Compounds 1 and 4 were found to be LOX inhibitors, compound 2 was a decomposer of the produced LHPOs, and compound 3 was both an inhibitor and a decomposer of the produced LHPOs.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1934-578X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1177/1934578X221115249