Prognostic value of an echocardiographic index reflecting right ventricular operating stiffness in patients with heart failure

Fujisawa, Ryosuke; Okada, Kazunori; Kaga, Sanae; Murayama, Michito; Nakabachi, Masahiro; Yokoyama, Shinobu; Nishino, Hisao; Tanemura, Asuka; Masauzi, Nobuo; Motoi, Ko; Ishizaka, Suguru; Chiba, Yasuyuki; Tsujinaga, Shingo; Iwano, Hiroyuki; Anzai, Toshihisa

Prognostic value of an echocardiographic index reflecting right ventricular operating stiffness in patients with heart failure

Fujisawa, Ryosuke; Okada, Kazunori; Kaga, Sanae et al.

Heart and vessels, 2021, 37(4), 583-592

Permalink : https://hdl.handle.net/2115/86963

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アクセス権	open access
URI	https://hdl.handle.net/2115/86963
タイトル	Prognostic value of an echocardiographic index reflecting right ventricular operating stiffness in patients with heart failure
著者	Fujisawa, Ryosuke ; Okada, Kazunori ; Kaga, Sanae ; Murayama, Michito ; Nakabachi, Masahiro ; Yokoyama, Shinobu ; Nishino, Hisao ; Tanemura, Asuka ; Masauzi, Nobuo ; Motoi, Ko ; Ishizaka, Suguru ; Chiba, Yasuyuki ; Tsujinaga, Shingo ; Iwano, Hiroyuki ; Anzai, Toshihisa
著者名 Fujisawa, Ryosuke
著者名 Okada, Kazunori
e-Rad_Researcher 60630978 著者名 Kaga, Sanae
著者名 Murayama, Michito
著者名 Nakabachi, Masahiro
著者名 Yokoyama, Shinobu
著者名 Nishino, Hisao
著者名 Tanemura, Asuka
著者名 Masauzi, Nobuo
著者名 Motoi, Ko
著者名 Ishizaka, Suguru
著者名 Chiba, Yasuyuki
e-Rad_Researcher 60844743 著者名 Tsujinaga, Shingo
e-Rad_Researcher 50622354 著者名 Iwano, Hiroyuki
e-Rad_Researcher 60232089 著者名 Anzai, Toshihisa
言語	英語
キーワード	Echocardiography
	Right ventricular stiffness
	Heart failure
	Prognosis
発行日	2021-10-16
出版者	Springer
収録物名	Heart and vessels
巻(号)	37(4)
ページ	583-592
抄録	Purpose We recently reported a noninvasive method for the assessment of right ventricular (RV) operating stiffness that is obtained by dividing the atrial-systolic descent of the pulmonary artery-RV pressure gradient (PRPGD(AC)) derived from the pulmonary regurgitant velocity by the tricuspid annular plane movement during atrial contraction (TAPM(AC)). Here, we investigated whether this parameter of RV operating stiffness, PRPGD(AC)/TAPM(AC), is useful for predicting the prognosis of patients with heart failure (HF). Methods We retrospectively included 127 hospitalized patients with HF who underwent an echocardiographic examination immediately pre-discharge. The PRPGD(AC)/TAPM(AC) was measured in addition to standard echocardiographic parameters. Patients were followed until 2 years post-discharge. The endpoint was the composite of cardiac death, readmission for acute decompensation, and increased diuretic dose due to worsening HF. Results 58 patients (46%) experienced the endpoint during follow-up. Univariable and multivariable Cox regression analyses demonstrated that the PRPGD(AC)/TAPM(AC) was associated with the endpoint. In a Kaplan-Meier analysis, the event rate of the greater PRPGD(AC)/TAPM(AC) group was significantly higher than that of the lesser PRPGD(AC)/TAPM(AC) group. In a sequential Cox analysis for predicting the endpoint's occurrence, the addition of PRPGD(AC)/TAPM(AC) to the model including age, sex, NYHA functional classification, brain natriuretic peptide level, and several echocardiographic parameters including tricuspid annular plane systolic excursion significantly improved the predictive power for prognosis. Conclusion A completely noninvasive index of RV operating stiffness, PRPGD(AC)/TAPM(AC), was useful for predicting prognoses in patients with HF, and it showed an incremental prognostic value over RV systolic function.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a post-peer-review, pre-copyedit version of an article published in Heart and Vessels. The final authenticated version is available online at: https://doi.org/10.1007/s00380-021-01960-6
PISSN	0910-8327
関連情報	PMID 34655317
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00380-021-01960-6