Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment

Miyaji, Hirofumi; Kanemoto, Yukimi; Hamamoto, Asako; Shitomi, Kanako; Nishida, Erika; Kato, Akihito; Sugaya, Tsutomu; Tanaka, Saori; Aikawa, Natsuha; Kawasaki, Hideya; Gohda, Syun; Ono, Hironobu

Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment

Miyaji, Hirofumi; Kanemoto, Yukimi; Hamamoto, Asako et al.

Scientific Reports, 2022, 12(1), 16721

Permalink : https://hdl.handle.net/2115/86986

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/86986
タイトル	Sustained antibacterial coating with graphene oxide ultrathin film combined with cationic surface-active agents in a wet environment
著者	Miyaji, Hirofumi ; Kanemoto, Yukimi ; Hamamoto, Asako ; Shitomi, Kanako ; Nishida, Erika ; Kato, Akihito ; Sugaya, Tsutomu ; Tanaka, Saori ; Aikawa, Natsuha ; Kawasaki, Hideya ; Gohda, Syun ; Ono, Hironobu
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
著者名 Kanemoto, Yukimi
著者名 Hamamoto, Asako
e-Rad_Researcher 70881449 著者名 Shitomi, Kanako
e-Rad_Researcher 50779882 著者名 Nishida, Erika
e-Rad_Researcher 40507571 著者名 Kato, Akihito
e-Rad_Researcher 10211301 著者名 Sugaya, Tsutomu
e-Rad_Researcher 90344522 著者名 Tanaka, Saori
著者名 Aikawa, Natsuha
e-Rad_Researcher 50322285 著者名 Kawasaki, Hideya
著者名 Gohda, Syun
著者名 Ono, Hironobu
言語	英語
発行日	2022-10-18
出版者	Nature Publishing Group
収録物名	Scientific Reports
巻(号)	12(1)
ページ	16721
抄録	Antimicrobial surfactants contained in mouthrinse have excellent efficacy, but are not retained on the tooth surface (are rinsed away) due to their low water resistance and thus do not exhibit sustained antibacterial activity. We have developed a new coating method using graphene oxide (GO) that retains the surfactant on the tooth surface even after rinsing with water, thus providing a sustained antibacterial effect. Ultra-thin films of GO and an antimicrobial agent were prepared by (1) applying GO to the substrate surface, drying, and thoroughly rinsing with water to remove excess GO to form an ultrathin film (almost a monolayer, transparent) on the substrate surface, then (2) applying antimicrobial cationic surface active agents (CSAAs) on the GO film to form a composite coating film (GO/CSAA). GO/CSAA formation was verified by scanning electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, and ζ-potential and contact angle measurements. GO/CSAA was effective at inhibiting the growth of oral pathogens for up to 7 days of storage in water, and antibacterial activity was recovered by reapplication of the CSAA. Antibacterial GO/CSAA films were also formed on a tooth substrate. The results suggest that GO/CSAA coatings are effective in preventing oral infections.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2045-2322
関連情報	PMID 36257962
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-022-21205-4