Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation

Kashiwakura, Jun-ichi; Koizumi, Nao; Saitoh, Kodai; Kagohashi, Kota; Sasaki, Yuto; Kobayashi, Fuki; Kawahara, Shoya; Yamauchi, Yukie; Kitai, Yuichi; Muromoto, Ryuta; Oritani, Kenji; Matsuda, Tadashi

Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation

Kashiwakura, Jun-ichi; Koizumi, Nao; Saitoh, Kodai et al.

Biochemical and biophysical research communications, 2021, 572, 80-85

Permalink : https://hdl.handle.net/2115/87011

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アクセス権	open access
URI	https://hdl.handle.net/2115/87011
タイトル	Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation
著者	Kashiwakura, Jun-ichi ; Koizumi, Nao ; Saitoh, Kodai ; Kagohashi, Kota ; Sasaki, Yuto ; Kobayashi, Fuki ; Kawahara, Shoya ; Yamauchi, Yukie ; Kitai, Yuichi ; Muromoto, Ryuta ; Oritani, Kenji ; Matsuda, Tadashi
e-Rad_Researcher 90373290 著者名 Kashiwakura, Jun-ichi
著者名 Koizumi, Nao
著者名 Saitoh, Kodai
著者名 Kagohashi, Kota
著者名 Sasaki, Yuto
著者名 Kobayashi, Fuki
著者名 Kawahara, Shoya
著者名 Yamauchi, Yukie
e-Rad_Researcher 90756165 著者名 Kitai, Yuichi
e-Rad_Researcher 30455597 著者名 Muromoto, Ryuta
e-Rad_Researcher 70324762 著者名 Oritani, Kenji
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	Mast cells
	IL-33
	Signal-transducing adaptor molecule-2
	ST2
	NF-kappa B
発行日	2021-10-01
出版者	Elsevier
収録物名	Biochemical and biophysical research communications
巻(号)	572
ページ	80-85
抄録	Signal-transducing adaptor protein (STAP)-2 is one of the STAP family adaptor proteins and ubiquitously expressed in a variety types of cells. Although STAP-2 is required for modification of Fc epsilon RI signal transduction in mast cells, other involvement of STAP-2 in mast cell functions is unknown, yet. In the present study, we mainly investigated functional roles of STAP-2 in IL-33-induced mast cell activation. In STAP-2-deficient, but not STAP-1-deficient, mast cells, IL-33-induced IL-6 and TNF-alpha production was significantly decreased compared with that of wild-type mast cells. In addition, STAP-2-deficiency greatly reduced TLR4-mediated mast cell activation and cytokine production. For the mechanisms, STAP-2 directly binds to IKK alpha after IL-33 stimulation, leading to elevated NF-kappa B activity. In conclusion, STAP-2, but not STAP-1, participates in IL-33-induced mast cells activation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0006-291X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2021.07.098