Clinicopathological characteristics and prognostic factors of ovarian granulosa cell tumors : A JSGO-JSOG joint study

Ebina, Yasuhiko; Yamagami, Wataru; Kobayashi, Yoichi; Tabata, Tsutomu; Kaneuchi, Masanori; Nagase, Satoru; Enomoto, Takayuki; Mikami, Mikio

Clinicopathological characteristics and prognostic factors of ovarian granulosa cell tumors : A JSGO-JSOG joint study

Ebina, Yasuhiko; Yamagami, Wataru; Kobayashi, Yoichi et al.

Gynecologic oncology, 2021, 163(2), 269-273

Permalink : https://hdl.handle.net/2115/87057

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アクセス権	open access
URI	https://hdl.handle.net/2115/87057
タイトル	Clinicopathological characteristics and prognostic factors of ovarian granulosa cell tumors : A JSGO-JSOG joint study
著者	Ebina, Yasuhiko ; Yamagami, Wataru ; Kobayashi, Yoichi ; Tabata, Tsutomu ; Kaneuchi, Masanori ; Nagase, Satoru ; Enomoto, Takayuki ; Mikami, Mikio
e-Rad_Researcher 90322809 著者名 Ebina, Yasuhiko
著者名 Yamagami, Wataru
著者名 Kobayashi, Yoichi
著者名 Tabata, Tsutomu
著者名 Kaneuchi, Masanori
著者名 Nagase, Satoru
著者名 Enomoto, Takayuki
著者名 Mikami, Mikio
言語	英語
キーワード	Lymph node metastasis
	Ovarian granulosa cell tumor
	Prognosis
	Surgery
発行日	2021-11-01
出版者	Elsevier
収録物名	Gynecologic oncology
巻(号)	163(2)
ページ	269-273
抄録	Objectives. The aim of this study was to elucidate the clinicopathological features of ovarian granulosa cell tu-mors (GCTs) and to identify the prognostic factors. Methods. The Japanese Society of Gynecologic Oncology (JSGO) conducted an observational retrospective co-hort study of women with GCTs enrolled in the Gynecological Tumor Registry of the Japan Society of Obstetrics and Gynecology (JSOG) between 2002 and 2015. Clinicopathological features, including lymph node metastasis, were evaluated. In addition, we performed a prognostic analysis of patients between 2002 and 2011 for whom survival data were available. Kaplan-Meier and multivariate Cox proportional hazards analyses were performed. Results. We identified 1426 patients with GCTs. Of the 222 patients who underwent lymph node dissection, 10 (4.5%) had lymph node metastasis. The incidence of lymph node metastasis in patients with pT1, pT2, and pT3 was 2.1%, 13.3%, and 26.7%, respectively (p < 0.001). Prognostic analysis was performed on 674 patients. In the multivariate Cox regression analysis, residual disease after initial surgery (hazard ratio (HR) = 10.39, 95% confidence interval (CI) = 3.15-34.29) and lymph node metastasis (HR = 5.58, 95% CI = 1.62-19.19) were independent risk factors for cancer-specific survival. Conclusions. In the initial surgery for GCTs, lymph node dissection can be omitted if the operative finding is pT1. In cases of pT2 or higher, lymph node dissection should be considered. Debulking is critical for achieving no gross residual tumor at the end of the surgery. (c) 2021 Elsevier Inc. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0090-8258
関連情報	PMID 34454726
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ygyno.2021.08.012