Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism

Nagata, Noriyuki; Sawamura, Hiryu; Morishita, Keitaro; Hosoya, Kenji; Yokoyama, Nozomu; Sasaoka, Kazuyoshi; Sasaki, Noboru; Nakamura, Kensuke; Ikenaka, Yoshinori; Takiguchi, Mitsuyoshi

Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism

Nagata, Noriyuki; Sawamura, Hiryu; Morishita, Keitaro et al.

Journal of veterinary medical science, 2022, 84(7), 954-959

Permalink : https://hdl.handle.net/2115/87105

このアイテムのアクセス数:323件（2026-01-14 07:01 集計）

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https://doi.org/10.1292/jvms.22-0131

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アクセス権	metadata only access
URI	https://hdl.handle.net/2115/87105
タイトル	Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism
著者	Nagata, Noriyuki ; Sawamura, Hiryu ; Morishita, Keitaro ; Hosoya, Kenji ; Yokoyama, Nozomu ; Sasaoka, Kazuyoshi ; Sasaki, Noboru ; Nakamura, Kensuke ; Ikenaka, Yoshinori ; Takiguchi, Mitsuyoshi
著者名 Nagata, Noriyuki
著者名 Sawamura, Hiryu
著者名 Morishita, Keitaro
著者名 Hosoya, Kenji
著者名 Yokoyama, Nozomu
著者名 Sasaoka, Kazuyoshi
著者名 Sasaki, Noboru
著者名 Nakamura, Kensuke
著者名 Ikenaka, Yoshinori
e-Rad_Researcher 70261336 著者名 Takiguchi, Mitsuyoshi
言語	英語
キーワード	canine
	Cushing’s syndrome
	hyperadrenocorticism
	urinary cortisol
発行日	2022-07
出版者	公益社団法人日本獣医学会 (The Japanese Society of Veterinary Science)
収録物名	Journal of veterinary medical science
巻(号)	84(7)
ページ	954-959
抄録	The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 x 10(-5) (range: 0.28-2.49) for 58 healthy dogs, and an upper reference limit of 1.98 x 10(-5) (90% confidence interval: 1.76-2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 x 10(-5), range 1.86-29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 x 10(-5), range 0.47-3.42, P < 0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 x 10(-5). The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 x 10-5, 95% confidence interval: 0.70-5.90, P=0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0916-7250
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.22-0131