Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague-Dawley rats?

Nakata, Hokuto; Nakayama, Shouta M. M.; Kataba, Andrew et al.

Journal of functional foods, 2022, 97, 105242

Permalink : https://hdl.handle.net/2115/87106

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/87106
タイトル
Does Moringa Oleifera affect element accumulation patterns and lead toxicity in Sprague-Dawley rats?
著者
Nakata, Hokuto ; Nakayama, Shouta M. M. ; Kataba, Andrew ; Toyomaki, Haruya ; Doya, Rio ; Yohannes, Yared Beyene ; Ikenaka, Yoshinori ; Ishizuka, Mayumi
著者名
Nakata, Hokuto
著者名
Nakayama, Shouta M. M.
著者名
Kataba, Andrew
著者名
Toyomaki, Haruya
著者名
Doya, Rio
著者名
Yohannes, Yared Beyene
著者名
Ikenaka, Yoshinori
e-Rad_Researcher
50332474
著者名
Ishizuka, Mayumi
言語
英語
キーワード
Lead poisoning
Moringa Oleifera
Sprague-Dawley
Protein carbonyl
ALAD
発行日
2022-10-01
出版者
Elsevier
収録物名
Journal of functional foods
巻(号)
97
ページ
105242
抄録
Moringa Oleifera (MO) has potential for nutritional and medical applications. We verified whether the administration of MO changed mineral accumulation patterns and mitigative effects of lead poisoning using Sprague-Dawley rats. MO leaves, aqueous leaf extracts, and seeds were administrated to rats in two different concentrations (100 and 600 mg/kg body weight/day) for 3 weeks. Element analysis, biochemical blood tests, oxidative-stress assessment, and blood delta-aminolevulinic acid dehydratase (ALAD) activity assays were performed after euthanasia and dissection. Although apparent changes in element accumulation patterns and biochemical parameters for hepatic and renal function assessments were not observed, lead-induced oxidative stress was significantly mitigated by the administration of MO leaves. The administration of high-dose MO leaves and seeds significantly recovered ALAD activity. Further investigations for potential mitigative effects of MO on lead toxicity and its mechanism are required.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1756-4646
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1016/j.jff.2022.105242