Fine-tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects

Kubota, Fumika; Satrialdi; Takano, Yuta; Maeki, Masatoshi; Tokeshi, Manabu; Harashima, Hideyoshi; Yamada, Yuma

Fine-tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects

Kubota, Fumika; Satrialdi; Takano, Yuta et al.

Journal of Biophotonics, 2022, 16(3), e202200119

Permalink : https://hdl.handle.net/2115/87127

このアイテムのアクセス数:421件（2026-08-18 15:39 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
https://doi.org/10.1002/jbio.202200119			47

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/87127
タイトル	Fine-tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects
著者	Kubota, Fumika ; Satrialdi ; Takano, Yuta ; Maeki, Masatoshi ; Tokeshi, Manabu ; Harashima, Hideyoshi ; Yamada, Yuma
著者名 Kubota, Fumika
著者名 Satrialdi
著者名 Takano, Yuta
著者名 Maeki, Masatoshi
e-Rad_Researcher 60311437 著者名 Tokeshi, Manabu
e-Rad_Researcher 00183567 著者名 Harashima, Hideyoshi
e-Rad_Researcher 60451431 著者名 Yamada, Yuma
言語	英語
キーワード	microfluidic device
	mitochondria
	nanocarrier
	photodynamic therapy
発行日	2022-09-01
出版者	Wiley-Blackwell
収録物名	Journal of Biophotonics
巻(号)	16(3)
ページ	e202200119
抄録	Photodynamic therapy (PDT) is a cancer therapy that uses a photosensitizer (PS) in the presence of oxygen molecules. Since singlet oxygen is highly reactive, it is important to deliver it to the target site. Thus, an efficient drug delivery system (DDS) is essential for enhancing the efficacy of such a treatment and protecting against the side effects of PDT. Here, we report on attempts to increase the therapeutic effect of PDT by using a DDS, a lipid nanoparticle (LNP). We prepared a porphyrin analog, rTPA (PS) that was encapsulated in LNPs using a microfluidic device. The findings indicated that the internal structure of the prepared particles changed depending on the amount of rTPA in LNPs. The photoactivity and cell-killing effect of PS in LNPs also changed when the amount of the cargo increased. These results suggest that the internal structure of LNPs is important factors that affect drug efficacy.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1864-063X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1002/jbio.202200119